Analgesic components of Saposhnikovia root (Saposhnikovia divaricata)
Analgesic components of Saposhnikovia root (Saposhnikovia divaricata)
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DOI：
10.1248/cpb.49.154
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发表时间：
2001-02-01
影响因子：
1.7
通讯作者：
Yamazaki, M
中科院分区：
文献类型：
--
作者：
Okuyama, E;Hasegawa, T;Yamazaki, M
通过小鼠扭体法活性定向分离，鉴定出菝葜科菝葜根茎的镇痛成分为色素、香豆素、聚乙炔和1-酰基甘油。此外，还分离出了两种新成分：异丙醇（divaricatol）和(3s)-hydroxydeltoin。以异丙醇、来布列尔和哈马多尔等激素为主要镇痛物质，口服剂量为1 mg/kg时，对小鼠扭体抑制作用最强。酰基甘油在5 mg/kg的剂量下也表现出明显的抑制作用。在部分药理试验中，该化合物通过尾压法和Randall & Selitto法表现出镇痛作用，其扭体抑制作用不被纳洛酮逆转。
By activity-oriented separation using the writhing method in mice, the analgesic components of Saposhnikovia root (Saposhnikovia divaricata Schischkin; Umbelliferae) were identified to be chromones, coumarins, polyacetylenes and 1-acylglycerols.Two new components, divaricatol and (3'S)-hydroxydeltoin, were also isolated. The most potent analgesia was observed in chromones such as divaricatol, ledebouriellol and hamaudol, which inhibited writhing inhibition at an oral dose of 1 mg/kg in mice. Acylglycerols also showed inhibition significantly at a dose of 5 mg/kg. In some pharmacological tests using sec-O-glucosylhamaudol, the compound showed analgesia by the tail pressure and the Randall & Selitto methods, and its writhing inhibition was not reversed by naloxone.