A comparison of EuroQol 5-Dimension health-related utilities using Italian, UK, and US preference weights in a patient sample
A comparison of EuroQol 5-Dimension health-related utilities using Italian, UK, and US preference weights in a patient sample
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DOI：
10.2147/ceor.s98226
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发表时间：
2016-01-01
影响因子：
2.1
通讯作者：
Fattore, Giovanni
中科院分区：
文献类型：
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作者：
Mozzi, Adelaide;Meregaglia, Michela;Fattore, Giovanni
与EuroQol五维3水平（EQ-5D-3L）工具相关的权重代表从一般人群样本中得出的健康状态偏好。没有计算每个国家的权重;但是，经验研究表明，各国之间存在差异。这项实证研究旨在使用克罗恩病患者样本，调查最近开发的意大利权重与英国和美国评分相比对健康相关效用计算的影响。该研究基于2012年至2013年在意大利进行的一项关于活动性克罗恩病患者（n=552）健康相关生活质量的调查。通过意大利算法计算的效用（平均值：0.76; SD：0.20;中位数：0.81）通常高于美国（平均值：0.69; SD：0.22;中位数：0.77）和英国（平均值：0.57; SD：0.32;中位数：0.69）的效用，除了极严重的健康状况，美国值超过意大利值。英国偏好权重产生的负面结果数量最多。所有三个值分布都是左偏的，因为与最严重的健康状态相关的分数非常低（即，三个或四个水平等于3）。正如预期的那样，尽管考虑了关税设置，但更严重的疾病（Harvey Bradshaw指数>16）降低了平均条件EQ-5D-3L指数（P < 0.0001）。EQ视觉模拟量表评分与EQ-5D-3L指数之间的Kendall等级相关性为正（P < 0.0001），尽管患者在回答EQ-5D-3L问题时往往比EQ视觉模拟量表更重视其健康相关生活质量。无论考虑的关税设置如何，普通最小二乘结果强调，更严重的疾病（哈维布拉德肖指数>16）降低了平均条件EQ-5D-3L指数（P < 0.0001）。结果显示，三个国家的关税之间的显着差异，特别是当严重的健康状况发生，这表明需要特定国家的优惠权重时，评估公用事业，这可能是有问题的，因为他们还没有计算出每个国家。
Weights associated with the EuroQol 5-Dimension 3-Level (EQ-5D-3L) instrument represent preferences for health states elicited from general population's samples. Weights have not been calculated for every country; however, empirical research shows that cross-country differences exist. This empirical study aims at investigating the impact of recently developed Italian weights in comparison with UK and US scores on health-related utility calculation using a sample of patients with Crohn's disease. The study is based on a survey on health-related quality of life in patients (n=552) affected by active Crohn's disease conducted in Italy from 2012 to 2013. Utilities computed through the Italian algorithm (mean: 0.76; SD: 0.20; median: 0.81) are generally higher than US (mean: 0.69; SD: 0.22; median: 0.77) and UK (mean: 0.57; SD: 0.32; median: 0.69) utilities, except for extremely severe health states where US values outweigh the Italian ones. UK preference weights generate the highest number of negative results. All the three value distributions are left-skewed due to very low scores associated with the most serious health states (ie, three or four levels equal to 3). As expected, despite the tariff set considered, more severe disease (Harvey Bradshaw Index >16) reduces the mean conditional EQ-5D-3L index (P < 0.0001). Kendall's rank correlation between EQ Visual Analog Scale score and EQ-5D-3L index is positive (P < 0.0001), even though patients tend to value their health-related quality of life more when responding to EQ-5D-3L questions than on EQ Visual Analog Scale. Regardless of the tariff set considered, ordinary least-square results highlight that more severe disease (Harvey Bradshaw Index >16) reduces the mean conditional EQ-5D-3L index (P < 0.0001). Results reveal remarkable differences among the three national tariff sets and especially when severe health states occur, suggesting the need for country-specific preference weights when evaluating utilities, which can be problematic since they have not been calculated for every country yet.