The burden of malaria epidemics and cost-effectiveness of interventions in epidemic situations in Africa
The burden of malaria epidemics and cost-effectiveness of interventions in epidemic situations in Africa
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DOI：
10.4269/ajtmh.2004.71.136
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发表时间：
2004-08-01
影响因子：
3.3
通讯作者：
Delacollette, C
中科院分区：
文献类型：
--
作者：
Worrall, E;Rietveld, A;Delacollette, C
迄今为止，量化疟疾流行病学和经济负担的尝试忽视了具体解决流行性疟疾的负担。此外，关于流行病干预措施的有效性和成本效益的数据极其有限。在流行病易发地区回答这些关键问题比在流行地区回答更具挑战性。利用现有的有限数据，我们估计，如果控制方案未得到实施或及时适时，在非洲，每年将有超过 1,200 万例疟疾发作和 155,000-310,000 例疟疾死亡归因于流行病，这相当于全世界估计每年疟疾病例的 4% 左右，占全球每年估计疟疾死亡人数的 12-25%，包括高达 15 岁以上人群估计全球每年疟疾死亡率的 50%。年龄。描述了疟疾流行病可能产生的经济影响，并审查了关于低传播或季节性传播地区干预措施的有效性和成本效益的有限证据。
Attempts to quantify the epidemiologic and economic burden of malaria have so far neglected to specifically address the burden of epidemic malaria. Moreover, the data on the effectiveness and cost-effectiveness of interventions in epidemics is extremely limited. Answering such key questions in an epidemic prone context is more challenging than doing so in endemic areas. Using the limited data available, we estimate that in Africa, there are more than 12 million malaria episodes and 155,000-310,000 malaria deaths per year attributable to epidemics if control options are not implemented or well timed, which is equivalent to some 4% of estimated annual malaria cases worldwide and 12-25% of estimated annual worldwide malaria deaths, including up to 50% of the estimated annual worldwide malaria mortality in persons > 15 years of age. The possible economic impact of malaria epidemics is described and the limited evidence on the effectiveness and cost-effectiveness of interventions in areas of low or seasonal transmission is reviewed.