Effects of supplementation with a combination of β-hydroxy-β-methyl butyrate, L-arginine, and L-glutamine on postoperative recovery of quadriceps muscle strength after total knee arthroplasty
Effects of supplementation with a combination of β-hydroxy-β-methyl butyrate, L-arginine, and L-glutamine on postoperative recovery of quadriceps muscle strength after total knee arthroplasty
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DOI：
10.6133/apjcn.2015.24.3.01
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发表时间：
2015-09-01
影响因子：
1.3
通讯作者：
Matsumura, Hajime
中科院分区：
文献类型：
--
作者：
Nishizaki, Kanae;Ikegami, Hitoshi;Matsumura, Hajime
目的：膝关节骨性关节炎患者行全膝关节置换术(TKA)后，股四头肌肌力立即下降。我们观察了联合补充β-羟基-β-甲基丁酸酯、L-精氨酸和L-谷氨酰胺(HMB/Arg/Gln)对TKA术后患者股四头肌肌力恢复的影响。方法：研究对象为23例接受全膝关节置换术的患者(女性12例，平均年龄70.5岁)。将患者随机分为对照组和补充HMB/Arg/Gln组(HMB/Arg/Gln组)。分别于术前5d、术后28d补充HMB/Arg/Gln或对照食品，分别于术前7d、术后14、28、42d测量股四头肌最大肌力。在研究期间，使用生活方式记录设备测量了总的能量消耗。两组进行康复治疗的方式相同。结果：对照组股四头肌最大肌力术前为1.1+/-0.62 Nm/kg，术后14天为0.7+/-0.9 Nm/kg(p=0.02)，HMB/Arg/Gln组为1.1+/-0.3 Nm/kg，术后14天为0.9+/-0.4 Nm/kg(P=0.02)。尽管对照组术后肌力显著下降，但HMB/Arg/Gln组没有。两组总能量消耗差异无统计学意义。结论：补充HMB/Arg/Gln可以抑制TKA术后肌力的丧失。运动和营养的干预似乎使患者能够保持股四头肌的力量。
Objectives: Total knee arthroplasty (TKA) performed in knee osteoarthritis patients is reported to be immediately followed by a decrease in quadriceps muscle strength. We investigated the effects of supplementation with a combination beta-hydroxy-beta-methyl butyrate, L-arginine, and L-glutamine (HMB/Arg/Gln) on the postoperative recovery of quadriceps muscle strength in patients after TKA. Methods: Study subjects were 23 patients (12 women; mean age: 70.5) who underwent TKA. The patients were randomly allocated into the control group or the group that consumed HMB/Arg/Gln supplementation (HMB/Arg/Gln group). HMB/Arg/Gln supplementation or control food were consumed for 5 days before the surgery and for 28 days after the surgery, and maximal quadriceps strength was measured at 7 days before the surgery, and at 14, 28 and 42 days after the surgery. During the study, total energy expenditure was measured using a lifestyle recording device. The two groups followed the rehabilitation in the same way. Results: The maximal quadriceps strength was 1.1 +/- 0.62 Nm/Kg before surgery and 0.7 +/- 0.9 Nm/Kg after surgery 14 days in the control group (p=0.02), and 1.1 +/- 0.3 Nm/Kg before surgery and 0.9 +/- 0.4 Nm/Kg after surgery 14 days in the HMB/Arg/Gln group. Although the control group experienced a significant loss of muscle strength after the surgery, the HMB/Arg/Gln group did not. There was no significant difference in total energy expenditure between the two groups. Conclusions: Consuming HMB/Arg/Gln supplementation may suppress the loss of muscle strength after TKA. Intervention with exercise and nutrition appears to enable patients to maintain their quadriceps strength.