Diabetic Retinopathy: Retina-Specific Methods for Maintenance of Diabetic Rodents and Evaluation of Vascular Histopathology and Molecular Abnormalities.
Diabetic Retinopathy: Retina-Specific Methods for Maintenance of Diabetic Rodents and Evaluation of Vascular Histopathology and Molecular Abnormalities.
复制标题
糖尿病性视网膜病：维持糖尿病啮齿动物的视网膜特异性方法和血管组织病理学和分子异常的评估。
DOI：
10.1002/9780470942390.mo140190
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发表时间：
2015-09-01
影响因子：
--
通讯作者：
Kern TS
中科院分区：
文献类型：
--
作者：
Veenstra A;Liu H;Lee CA;Du Y;Tang J;Kern TS
糖尿病视网膜病变是视力损害的主要原因，随着越来越多的人患糖尿病，视力损害的患病率继续增加。尽管视力的重要性，视网膜是身体中最小的组织之一，并且已经开发了研究视网膜病变的专门技术。本章将总结几种方法，用于（i）诱导糖尿病，（ii）在典型血管组织病理学发展所需的整个月内维持糖尿病动物，（iii）评价糖尿病视网膜病变的血管组织病理学，（iv）定量视网膜病变发展中涉及的异常。
Diabetic retinopathy is a major cause of visual impairment, which continues to increase in prevalence as more and more people develop diabetes. Despite the importance of vision, the retina is one of the smallest tissues in the body, and specialized techniques to study the retinopathy have been developed. This chapter will summarize several methods used to (i) induce diabetes, (ii) maintain the diabetic animals throughout the months required for the development of typical vascular histopathology, (iii) evaluate vascular histopathology of diabetic retinopathy, and (iv) quantitate abnormalities implicated in the development of the retinopathy.