The relationship between dementia and direct involvement of the hippocampus and amygdala in Parkinson's disease
The relationship between dementia and direct involvement of the hippocampus and amygdala in Parkinson's disease
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DOI：
10.1212/wnl.49.6.1570
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发表时间：
1997-12-01
期刊：
影响因子：
9.9
通讯作者：
Lees, AJ
中科院分区：
文献类型：
--
作者：
Churchyard, A;Lees, AJ
严重痴呆影响了所有帕金森病（PD）患者的10%至20%，在65岁及以上的患者中尤为常见。在一项临床病理研究中，我们将27例无阿尔茨海默病改变的PD患者的路易小体、路易神经突、神经原纤维缠结、神经斑块、胶质变和海马和杏仁核神经元的密度与迷你精神状态检查评分和DSM-III痴呆评分相关联。在前扣带回检查皮层路易体密度。认知障碍的程度与海马CA2区Lewy神经突的密度相关，提出了齿状回、内嗅皮层、间隔核和下丘脑与CA1区之间连接的破坏可能导致PD患者痴呆。
Severe dementia affects 10 to 20% of all patients with Parkinson's disease (PD) and is particularly common in those aged 65 years and over. In a clinicopathologic study, we correlated Mini-Mental State Examination scores and DSM-III dementia ratings with the density of Lewy bodies, Lewy neurites, neurofibrillary tangles, neuritic plaques, gliosis, and neurons in the hippocampus and amygdala of 27 PD patients without Alzheimer's disease changes. Cortical Lewy body densities were examined in the anterior cingulate gyrus. The degree of cognitive impairment was correlated with the density of Lewy neurites in the CA2 hippocampal field, raising the possibility that disruption of the connection between the dentate gyrus, entorhinal cortex, septal nuclei, and hypothalamus and the CA1 field contributes to dementia in PD.