EXPANSION OF THE CD4-,CD8- GAMMA-DELTA T-CELL SUBSET IN THE SPLEENS OF MICE DURING NONLETHAL BLOOD-STAGE MALARIA
EXPANSION OF THE CD4-,CD8- GAMMA-DELTA T-CELL SUBSET IN THE SPLEENS OF MICE DURING NONLETHAL BLOOD-STAGE MALARIA
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DOI：
10.1002/eji.1830230817
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发表时间：
1993-08-01
影响因子：
5.4
通讯作者：
WEIDANZ, WP
中科院分区：
文献类型：
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作者：
VANDERHEYDE, HC;ELLOSO, MM;WEIDANZ, WP
Splenic gammadelta T cells (CD4 , CD8 ) increased more that 10-fold upon resolution of either Plasmodium chabaudi adami or P c. chabaudi infections in C57BL/6 mice compared to controls. Similarly, a 10- to 20-fold expansion of the gammadelta T cell population was observed in beta2-microglobulin deficient (beta2-m0/0) mice that had resolved P c. adami, P c. chabaudi or P yoelii yoelii infections. In contrast, increases in the number of splenic alphabeta T cells in these infected mice were only two to three-fold indicating a differential expansion of the gammadelta T cell subset during malaria. Because nucleated cells Of beta2-M0/0 mice lack surface expression of major histocompatibility complex class I and class Ib glycoproteins, our findings suggest that antigen presentation by these glycoproteins is not necessary for the increasing number of gammadelta T cells. Our observation that after resolution of P c. adami malaria, C57BL/6 mice depleted of CD8+ cells by monoclonal antibody treatment had lower numbers of gammadelta T cells than untreated controls suggests that the demonstrated lack of CD8+ cells in beta2-M0/0 mice does not contribute to the expansion of the gammadelta T cell population during non-lethal malaria.
