Falciparum but not vivax malaria increases the risk of hypertensive disorders of pregnancy in women followed prospectively from the first trimester.
Falciparum but not vivax malaria increases the risk of hypertensive disorders of pregnancy in women followed prospectively from the first trimester.
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DOI：
10.1186/s12916-021-01960-3
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发表时间：
2021-04-27
期刊：
影响因子：
9.3
通讯作者：
McGready R
中科院分区：
文献类型：
--
作者：
Harrington WE;Moore KA;Min AM;Gilder ME;Tun NW;Paw MK;Wiladphaingern J;Proux S;Chotivanich K;Rijken MJ;White NJ;Nosten F;McGready R
疟疾和妊娠期高血压疾病(HDoP)影响全世界数百万的怀孕，特别是那些年轻的第一次怀孕的母亲。小型病例对照研究表明恶性疟疾与先兆子痫的风险呈正相关，但缺乏大型前瞻性分析。我们对妊娠期疟疾与HDoP的发展之间的关系进行了大规模前瞻性跟踪队列研究。1986年至2016年，居住在泰国和缅甸边境的孕妇在产前诊所接受了跟踪调查。泰缅边境是疟疾季节性传播率较低的地区。对所有妇女进行Logistic回归分析，并根据妊娠情况进行分层，分析妊娠期恶性疟和间日疟与妊娠期高血压、先兆子痫或子痫发病几率的关系。在怀孕前三个月分娩并每两周进行一次跟踪调查的妇女中，有23,262例单胎怀孕。在多胎妊娠中，恶性疟疾与妊娠高血压有关(调整后的优势比(AOR)为2.59，95%可信区间为1.59-4.23)，而在初产妇中，恶性疟疾与先兆子痫/子痫的综合结局相关(调整后优势比为2.61，95%可信区间为1.01-6.79)。相比之下，间日疟和HDoP之间没有关联。妊娠期恶性疟疾与妊娠期高血压疾病有关，但与间日疟无关。
Malaria and hypertensive disorders of pregnancy (HDoP) affect millions of pregnancies worldwide, particularly those of young, first-time mothers. Small case-control studies suggest a positive association between falciparum malaria and risk of pre-eclampsia but large prospective analyses are lacking. We characterized the relationship between malaria in pregnancy and the development of HDoP in a large, prospectively followed cohort. Pregnant women living along the Thailand-Myanmar border, an area of low seasonal malaria transmission, were followed at antenatal clinics between 1986 and 2016. The relationships between falciparum and vivax malaria during pregnancy and the odds of gestational hypertension, pre-eclampsia, or eclampsia were examined using logistic regression amongst all women and then stratified by gravidity. There were 23,262 singleton pregnancies in women who presented during the first trimester and were followed fortnightly. Falciparum malaria was associated with gestational hypertension amongst multigravidae (adjusted odds ratio (AOR) 2.59, 95%CI 1.59–4.23), whereas amongst primigravidae, it was associated with the combined outcome of pre-eclampsia/eclampsia (AOR 2.61, 95%CI 1.01–6.79). In contrast, there was no association between vivax malaria and HDoP. Falciparum but not vivax malaria during pregnancy is associated with hypertensive disorders of pregnancy.
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DOI：
10.1038/nrneph.2014.102
发表时间：
2014-08
期刊：
Nature reviews. Nephrology
影响因子：
--
作者：
Chaiworapongsa T;Chaemsaithong P;Yeo L;Romero R
通讯作者：
Romero R
影响因子：
9.3
作者：
Moore KA;Fowkes FJI;Wiladphaingern J;Wai NS;Paw MK;Pimanpanarak M;Carrara VI;Raksuansak J;Simpson JA;White NJ;Nosten F;McGready R
通讯作者：
McGready R
影响因子：
56.3
作者：
McGready, R.;Lee, S. J.;Nosten, F. H.
通讯作者：
Nosten, F. H.
影响因子：
9.3
作者：
Moore KA;Simpson JA;Wiladphaingern J;Min AM;Pimanpanarak M;Paw MK;Raksuansak J;Pukrittayakamee S;Fowkes FJI;White NJ;Nosten F;McGready R
通讯作者：
McGready R
影响因子：
15.8
作者：
Muehlenbachs, Atis;Mutabingwa, Theonest K.;Duffy, Patrick E.
通讯作者：
Duffy, Patrick E.