PRL-3 Phosphatase and Cancer Metastasis
PRL-3 Phosphatase and Cancer Metastasis
复制标题
DOI：
10.1002/jcb.22913
复制
发表时间：
2010-12-01
影响因子：
4
通讯作者：
Zeng, Qi
中科院分区：
文献类型：
--
作者：
Al-Aidaroos, Abdul Qader O.;Zeng, Qi
再生肝磷酸酶（PRL）家族成员的表达失调与多种人类癌症的转移进展有关。重要的是，PRL-1和PRL-3都具有驱动转移进展关键步骤的能力。然而，很少有人知道这类新兴的双特异性磷酸酶的调节和致癌机制。这篇前景文章详细介绍了PRL在转移级联反应中的参与，控制PRL表达的调控机制，以及最近使用生物化学和高通量方法表征PRL调节途径和底物的努力。最后对该家族的抗癌治疗现状和前景进行了展望。J.细胞。111：1087-1098，2010. (C)2010 Wiley-Liss，Inc.
The deregulated expression of members of the phosphatase of regenerating liver (PRL) family has been implicated in the metastatic progression of multiple human cancers. Importantly, PRL-1 and PRL-3 both possess the capacity to drive key steps in metastatic progression. Yet, little is known about the regulation and oncogenic mechanisms of this emerging class of dual-specificity phosphatases. This prospect article details the involvement of PRLs in the metastatic cascade, the regulatory mechanisms controlling PRL expression, and recent efforts in the characterization of PRL-modulated pathways and substrates using biochemical and high-throughput approaches. Current advances and future prospects in anti-cancer therapy targeting this family are also discussed. J. Cell. Biochem. 111: 1087-1098, 2010. (C) 2010 Wiley-Liss, Inc.