ANTIBODIES ELICITED BY PNEUMOCOCCAL ANTIGENS BEAR AN ANTI-DNA-ASSOCIATED IDIOTYPE
ANTIBODIES ELICITED BY PNEUMOCOCCAL ANTIGENS BEAR AN ANTI-DNA-ASSOCIATED IDIOTYPE
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DOI：
10.1172/jci115088
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发表时间：
1991-03-01
影响因子：
15.9
通讯作者：
DIAMOND, B
中科院分区：
文献类型：
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作者：
GRAYZEL, A;SOLOMON, A;DIAMOND, B
在老鼠和人类狼疮中都有证据表明，抗DNA抗体的产生可能是由环境抗原触发的。为了进一步探索这一点，我们研究了10名用多价肺炎球菌多糖疫苗免疫的非自身免疫者的血清。所有10名患者都表现出携带抗DNA相关独特型的抗肺炎球菌抗体滴度上升。抗肺炎球菌反应是特异的，因为没有检测到独特型抗破伤风抗体。此外，免疫后血清中未检测到抗DNA抗体。对具有共同独特型的抗肺炎球菌抗体和抗DNA抗体的分子分析将有助于阐明外来抗原如何导致易感个体产生抗DNA抗体。
There is evidence in both murine and human lupus that the production of anti-DNA antibodies may be triggered by environmental antigens. To explore this further, we studied the serum of 10 nonautoimmune individuals immunized with a polyvalent pneumococcal polysaccharide vaccine. All 10 patients showed a rise in the titer of antipneumococcal antibodies bearing an anti-DNA-associated idiotype. The antipneumococcal response was specific as no idiotypic antitetanus antibodies were detected. Furthermore, no anti-DNA antibodies were present in postvaccination sera. The molecular analysis of antipneumococcal and anti-DNA antibodies bearing a common idiotype will help elucidate how foreign antigen might lead to the production of anti-DNA antibodies in susceptible individuals.