Risk factors for rate of decline in FEV1 in adults with cystic fibrosis
Risk factors for rate of decline in FEV1 in adults with cystic fibrosis
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DOI：
10.1016/j.jcf.2012.03.009
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发表时间：
2012-09-01
影响因子：
5.2
通讯作者：
Morgan, Wayne J.
中科院分区：
文献类型：
--
作者：
Konstan, Michael W.;Wagener, Jeffrey S.;Morgan, Wayne J.
背景资料：以前我们使用囊性纤维化的流行病学研究评估了儿童和青少年FEV 1下降的危险因素（J Pediatr 2007;151：134-139）;当前研究评估了成人的风险因素。方法：使用混合模型回归评估了18-24岁和>= 25岁的FEV 1在3-5.5年内下降的风险因素。18- 24岁（n=2793）和>= 25岁（n=1368）的FEV 1平均下降率（%预测值/年）分别为-1.92和-1.45。18- 24岁组B.洋葱炎、胰酶使用、多重耐药铜绿假单胞菌、咳嗽、粘液型铜绿假单胞菌和女性预测下降幅度更大;低基线FEV 1和鼻窦炎预测下降幅度较小。对于≥ 25岁组，仅使用胰酶预测下降幅度较大;低基线FEV 1和鼻窦炎预测下降幅度较小。
Background: Previously we assessed risk factors for FEV1 decline in children and adolescents using the Epidemiologic Study of Cystic Fibrosis (J Pediatr 2007;151:134-139); the current study assessed risk factors in adults.Methods: Risk factors for FEV1 decline over 3-5.5 years for ages 18-24 and >= 25 years were assessed using mixed-model regression.Results: Mean rates of FEV1 decline (% predicted/year) were -1.92 for ages 18-24y (n=2793) and -1.45 for ages >= 25y (n=1368). For the 18-24y group, B. cepacia, pancreatic enzyme use, multidrug-resistant P. aeruginosa, cough, mucoid P. aeruginosa, and female sex predicted greater decline; low baseline FEV1 and sinusitis predicted less decline. For the >= 25y group, only pancreatic enzyme use predicted greater decline; low baseline FEV1 and sinusitis predicted less decline.Conclusions: Risk factors for FEV, decline in adults