Associations among prenatal stress, maternal antioxidant intakes in pregnancy, and child temperament at age 30 months.
Associations among prenatal stress, maternal antioxidant intakes in pregnancy, and child temperament at age 30 months.
复制标题
产前压力、孕期母亲抗氧化剂摄入量和 30 个月大儿童气质之间的关联。
DOI：
10.1017/s2040174417000411
复制
发表时间：
2017
影响因子：
1.7
通讯作者：
BosquetEnlow,M
中科院分区：
文献类型：
--
作者：
Lipton,LR;Brunst,KJ;Kannan,S;Ni,Y-M;Ganguri,HB;Wright,RJ;BosquetEnlow,M
产前压力和产前营养对胎儿发育都有明显的影响，并对儿童神经发育和行为产生影响。然而，很少有研究探讨他们的联合影响，尽管有证据表明潜在的相互作用。我们在一个社会人口统计学上多样化的妊娠队列（N=137对母子）中研究了产前压力、产前抗氧化剂摄入量和儿童气质之间的关系。在怀孕中期，母亲完成了对最近负面生活事件的评估，作为产前压力的衡量标准，并评估了产前饮食。当孩子30个月大时，母亲完成了儿童早期行为量表-非常简短的表格，该表格提供了儿童消极情感，努力控制和冲动/外向性的评分。线性回归检验了母亲产前负性生活事件与儿童气质之间的关联，以及母亲产前抗氧化剂摄入量（维生素A、C和E、镁、锌、硒、β-胡萝卜素）的影响。分析显示，母亲产前负性生活事件的增加与儿童负性情感的增加相关（β=0.08，P=0.009），但与儿童努力控制（β=-0.03，P=0.39）或冲动/外向（β=0.04，P=0.14）无关。产前锌和硒的摄入量改变了这种效应：在锌和硒摄入量较低的情况下，母亲暴露于产前负性生活事件与较高的儿童负性情感相关。对维生素A和C的修饰效果接近显著性。研究结果表明，怀孕期间压力暴露增加和抗氧化剂摄入量减少的结合增加了儿童气质负面情感增强的可能性。在怀孕期间增加抗氧化剂的摄入量可以防止产前压力对儿童气质的影响。
Prenatal stress and prenatal nutrition each have demonstrable impact on fetal development, with implications for child neurodevelopment and behavior. However, few studies have examined their joint influences despite evidence of potential interactive effects. We examined associations among prenatal stress, prenatal antioxidant intakes, and child temperament in a sociodemographically diverse pregnancy cohort (N=137 mother–child dyads). In mid-pregnancy, mothers completed an assessment of recent negative life events as a measure of prenatal stress and an assessment of prenatal diet. When the children were 30 months of age, mothers completed the Early Childhood Behavior Questionnaire-Very Short form, which provides scores on child Negative Affectivity, Effortful Control, and Surgency/Extraversion. Linear regressions tested associations between maternal prenatal negative life events and child temperament, and effect modification by maternal prenatal antioxidant intakes (vitamins A, C, and E, magnesium, zinc, selenium, β-carotene). Analyses revealed that increased maternal prenatal negative life events were associated with higher child Negative Affectivity (β=0.08, P=0.009) but not with child Effortful Control (β=−0.03, P=0.39) or Surgency/Extraversion (β=0.04, P=0.14). Prenatal intakes of zinc and selenium modified this effect: Maternal exposure to prenatal negative life events was associated with higher child Negative Affectivity in the presence of lower intakes of zinc and selenium. Modification effects approached significance for vitamins A and C. The results suggest that the combination of elevated stress exposures and lower antioxidant intakes in pregnancy increases the likelihood of heightened child temperamental negative affectivity. Increased antioxidant intakes during pregnancy may protect against influences of prenatal stress on child temperament.