PGC-1α mRNA level and oxidative capacity of the plantaris muscle in rats with metabolic syndrome, hypertension, and type 2 diabetes.
PGC-1α mRNA level and oxidative capacity of the plantaris muscle in rats with metabolic syndrome, hypertension, and type 2 diabetes.
复制标题
DOI：
10.1267/ahc.10041
复制
发表时间：
2011-04-28
影响因子：
2.4
通讯作者：
Ishihara A
中科院分区：
文献类型：
--
作者：
Nagatomo F;Fujino H;Kondo H;Gu N;Takeda I;Ishioka N;Tsuda K;Ishihara A
我们检查了 15 周龄对照 (WR)、代谢综合征 (CP)、高血压 (SHR) 和 2 型糖尿病 (GK) 大鼠跖肌中的纤维分布和过氧化物酶体增殖物激活受体（PPARα 和 PPARδ/β）以及 PPARγ 共激活剂-1α (PGC-1α) 的 mRNA 水平。与WR和CP大鼠相比，SHR和GK大鼠肌肉深层区域表现出较低百分比的高氧化I型和IIA型纤维，以及较高百分比的低氧化型IIB纤维。与 WR 大鼠相比，CP、SHR 和 GK 大鼠的肌肉表面区域表现出较低百分比的高氧化型 IIA 纤维和较高的低氧化型 IIB 纤维百分比。与WR大鼠相比，SHR和GK大鼠的肌肉氧化酶活性较低。 SHR 大鼠的肌肉具有最低的 PPARδ/β mRNA 水平。此外，与WR和CP大鼠相比，SHR和GK大鼠的肌肉中PGC-1α mRNA水平较低。我们得出结论，高血压和2型糖尿病大鼠的跖肌氧化能力较低，这与PGC-1α mRNA水平降低有关。
We examined the fiber profiles and the mRNA levels of peroxisome proliferator-activated receptors (PPARα and PPARδ/β) and of the PPARγ coactivator-1α (PGC-1α) in the plantaris muscles of 15-week-old control (WR), metabolic syndrome (CP), hypertensive (SHR), and type 2 diabetic (GK) rats. The deep regions in the muscles of SHR and GK rats exhibited lower percentages of high-oxidative type I and IIA fibers and higher percentages of low-oxidative type IIB fibers compared with WR and CP rats. The surface regions in the muscles of CP, SHR, and GK rats exhibited lower percentages of high-oxidative type IIA fibers and higher percentages of low-oxidative type IIB fibers compared with WR rats. The muscles of SHR and GK rats had lower oxidative enzyme activity compared with WR rats. The muscles of SHR rats had the lowest PPARδ/β mRNA level. In addition, the muscles of SHR and GK rats had lower PGC-1α mRNA level compared with WR and CP rats. We concluded that the plantaris muscles of rats with hypertension and type 2 diabetes have lower oxidative capacity, which is associated with the decreased level of PGC-1α mRNA.