Loneliness and psychotic experiences in a general population sample
Loneliness and psychotic experiences in a general population sample
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DOI：
10.1016/j.schres.2020.01.018
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发表时间：
2020-04-01
影响因子：
4.5
通讯作者：
DeVylder, Jordan
中科院分区：
文献类型：
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作者：
Narita, Zui;Stickley, Andrew;DeVylder, Jordan
孤独感的增加与包括精神障碍在内的常见精神障碍有关。然而，迄今为止，关于孤独感与精神病经历（PE）发生之间关系的信息还很少，特别是在考虑了混杂因素后。为了解决这一缺陷，当前的研究调查了美国一般人群样本（N = 974）中的 PE 与孤独感之间的关系。我们利用社会人口因素、不良童年经历和常见精神障碍的分层调整，拟合了三个回归模型来研究孤独感和体育锻炼之间的关联。即使在最高水平的调整下，孤独感也与任何 PE 的几率增加显着相关（OR = 1.25，95% CI = 1.13–1.39）。这同样适用于孤独感和妄想情绪之间的关联（OR = 1.29，95% CI = 1.15–1.44）。对于参考和迫害妄想、控制妄想和幻觉，在调整社会人口因素、不良童年经历和常见精神障碍后，没有显着关联。这些结果表明，孤独感的增加与 PE 相关，尤其是妄想情绪。未来的研究应采用纵向数据和生物学测量来检查潜在的因果关系和潜在机制。
Increased loneliness has been associated with common mental disorders including psychotic disorders. However, as yet, little information is available on the association between loneliness and the occurrence of psychotic experiences (PEs), especially when adjusted for confounding factors. To address this deficit, the current study examined the relationship between PEs and loneliness in a general population sample in the United States (N = 974). We fitted three regression models to examine the associations between loneliness and PEs, using hierarchical adjustments for sociodemographic factors, adverse childhood experiences, and common mental disorders. Even at the highest level of adjustment, loneliness was significantly associated with increased odds for any PEs (OR = 1.25, 95% CI = 1.13–1.39). The same applied to the association between loneliness and delusional mood (OR = 1.29, 95% CI = 1.15–1.44). For delusion of reference and persecution, delusions of control, and hallucinations, there were no significant associations when adjusted for sociodemographic factors, adverse childhood experiences, and common mental disorders. These results suggest that increased loneliness is associated with PEs, particularly delusional mood. Future studies should employ longitudinal data and biological measures to examine potential causal relationships and underlying mechanisms.