Dietary Whey Protein Lows the Risk for Metabolic Disease in Mice Fed a High-Fat Diet
Dietary Whey Protein Lows the Risk for Metabolic Disease in Mice Fed a High-Fat Diet
复制标题
DOI：
10.3945/jn.110.133736
复制
发表时间：
2011-04-01
影响因子：
4.2
通讯作者：
Pearson, Kevin J.
中科院分区：
文献类型：
--
作者：
Shertzer, Howard G.;Woods, Sally E.;Pearson, Kevin J.
食用高脂肪(IF)饮食会导致过度体重增加、肥胖以及与发展成2型糖尿病和脂肪肝相关的代谢并发症。本研究评价了乳清蛋白(WPI)对喂食HF饲料的小鼠全身能量平衡和代谢物c电荷的影响。雌性C57BL/6小鼠接受I-IF喷射机11wk，加或不加100g WPI/L饮用水。检测能量消耗、糖脂代谢。WPI小鼠的体重增加率和体脂百分比较低，瘦体重较大，但能量消耗没有变化。这些结果表明，WPI小鼠的基础代谢率较高。呼吸商和肝脏线粒体呼吸对WPI的健康影响反映在脂肪性河病和2型糖尿病的早期生物标志物中。来自WPI小鼠的Rivers显著减少了肝脏的脂滴数量和非极性脂的沉积。此外，WPI还改善了糖耐量和胰岛素敏感性。我们的结论是，在接受HF饮食的小鼠中，摄入WPI会导致更高的基础代谢率和饮食脂质代谢的改变。由于WPI小鼠的肝脏骨质疏松症和胰岛素抵抗较少，WPI膳食补充剂可能在减缓脂肪肝疾病和2型糖尿病的发展方面有效。J.Nutr.141.582-587,2011年。
Consuming a high-fat ( IF) diet produces excessive weight gain, ad posity, and metabolic complications associated w th r ss for developing type 2 diabetes and fatty liver disease. This study evaluated the influence of whey protein so ate (WPI) on systemic energy balance and metabol c charges in mice fed a HF diet. Female C57BL/6 mice received for 11 wk a I-IF jet with or without 100 g WPI/L drinking water. Energy consumption and glucose and lipid metabolism were examined. WPI mice had lower rates of body weight gain and percent body fa: and greater lean body mass, although energy consumption was unchanged These results were cars stoat w th WPI mice having higher basal metabolic rates. respiratory quotients, and hepatic mitochondria a respiration Health implications for WPI were reflected in early biomarkers for fatty river disease and type 2 diabetes. rivers from WPI mice had significantly fewer hepatic lipid droplet numbers and less deposition of nonpolar lipids. Furthermore, WPI improved glucose tolerance and insulin sensitivity. We conclude that in mice receiving a HF diet, consumption of WPI results in higher basal metabolic rates and altered metabolism of dietary lipids. Because WPI mice had less hepatosteatosis and insulin resistance, WPI dietary supplements may be effective in slowing the development of fatty liver d sease and type 2 diabetes. J. Nutr. 141. 582-587, 2011.