Breast cancer and breastfeeding: results from an Australian case-control study.
Breast cancer and breastfeeding: results from an Australian case-control study.
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乳腺癌和母乳喂养：澳大利亚病例对照研究的结果。
DOI：
10.1093/oxfordjournals.aje.a115329
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发表时间：
1989
影响因子：
5
通讯作者：
Christopher Bain
中科院分区：
文献类型：
--
作者：
Victor Sikind;Frank Schofield;Dorte E. Rice;Christopher Bain
1981年至1985年在澳大利亚布里斯班进行了一项关于乳腺癌、饮食和哺乳史的病例对照研究。从私营和公共卫生保健部门招募病例。分析了从选民名册中选出的459例病例和1,091例对照的母乳喂养史。观察到任何哺乳期与无哺乳期的比值比为0.85（95%置信区间0.55-1.30），未提示随持续时间增加呈单调趋势。这一估计值通过多元logistic回归分析仅略有改变。第一个活产婴儿的母乳喂养存在统计学显著的非线性关联（χ 2 = 14.8，df = 6; p <0.05），小于1个月的哺乳期的比值比略微升高，1个月至3个月的哺乳期的比值比降低，母乳喂养超过9个月的妇女的比值比略微升高。绝经前妇女的结果与绝经后妇女的结果非常相似。与其他最近的研究一起，这些结果表明，哺乳可能在降低乳腺癌风险方面发挥适度的直接或间接作用。
A case-control study of breast cancer, diet, and lactational history was carried out in Brisbane, Australia, between 1981 and 1985. Cases were recruited from both the private and the public health care sectors. The breastfeeding histories of 459 cases and 1,091 controls selected from the electoral roll were analyzed. An odds ratio of 0.85 (95% confidence interval 0.55-1.30) for any lactation versus no lactation was observed, with no suggestion of a monotonic trend with increasing duration. This estimate was only slightly altered by multiple logistic regression analysis. A statistically significant nonlinear association was noted for breastfeeding of the first liveborn child (chi 2 = 14.8, df = 6; p less than 0.05), with a slightly elevated odds ratio for lactations of less than one month, a lowered odds ratio for lactations of one month to three months, and a weakly elevated odds ratio in women breastfeeding for more than nine months. Results for premenopausal women were very similar to those for postmenopausal women. Taken together with other recent studies, these results suggest that lactation may play a modest direct or indirect part in reducing the risk of breast cancer.