Spontaneous amyloidosis in senile NSY mice
Spontaneous amyloidosis in senile NSY mice
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老年 NSY 小鼠自发性淀粉样变性
DOI：
10.1111/j.1440-1827.1993.tb01135.x
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发表时间：
1993
影响因子：
2.2
通讯作者：
T. Takeda
中科院分区：
文献类型：
--
作者：
K. Shimizu;H. Morita;Toshiyuki Niwa;Kenji Maeda;M. Shibata;K. Higuchi;T. Takeda
老年名古屋、柴田、安田（NSY）小鼠发生淀粉样变性，并死于淀粉样变性导致的肾衰竭。柴田等人在1980年首次报道了NSY小鼠作为实验性先天性糖尿病小鼠。这项研究质疑NSY小鼠是否死于糖尿病肾病。作者调查了这些鼠的寿命和死亡原因。NSY小鼠的寿命为618.7 ± 72.5天。存活超过400天的NSY小鼠表现出血尿素氮升高和肾小球中大量淀粉样蛋白沉积。NSY小鼠死于肾淀粉样变性。免疫学方法显示，AApoAll在NSY小鼠的淀粉样蛋白沉积中是明显的。除肾脏外，在舌、食管、胃、小肠、大肠、直肠、肺、心脏和肾上腺中也发现淀粉样蛋白沉积。在肝脏和脾脏中发现轻度淀粉样沉积。NSY小鼠中最主要的淀粉样蛋白沉积见于肾小球。从淀粉样蛋白沉积分布的角度来看，NSY小鼠与其他自发性淀粉样蛋白小鼠相比是独特的。
Senile Nagoya, Shibata, Yasuda (NSY) mice developed amyloidosis and died from renal failure as a result of amyloidosis. NSY mice were first reported as experimental congenital diabetic mice by Shibata et al. in 1980. This study questioned whether NSY mice died from diabetic nephropathy. The authors of the present study investigated the life span and cause of death in these micde. The life span of NSY mice was found to be 618.7 ± 72.5 days. NSY mice that lived for more than 400 days showed rising blood uread nitrogen and large amounts of amyloid deposits in the glomerulus of the kidneys. NSY mice died of renal amyloidosis. Immunological methods revealed that AApoAll was evident in the amyloid deposits of NSY mice. Apart from the kidneys, amyloid deposition was also found in the tongue, esojphagus, stomach, small intestine, large intestine, rectum, lung, heart and adrenal glands. Amyloid deposits were found to a slight degree In the liver and the spleen. The most dominant amyloid deposition in NSY mice was seen in the glomerulus of the kidneys. From the point of view of amyloid depositional distribution, NSY mice were unique compared with other spontaneous amyloid mice.