Impact of Patient Age and Histological Type on Radioactive Iodine Avidity of Recurrent Lesions of Differentiated Thyroid Carcinoma
Impact of Patient Age and Histological Type on Radioactive Iodine Avidity of Recurrent Lesions of Differentiated Thyroid Carcinoma
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DOI：
10.1097/rlu.0000000000002078
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发表时间：
2018-07-01
影响因子：
10.6
通讯作者：
Kodera, Yasuhiro
中科院分区：
文献类型：
--
作者：
Nakanishi, Kenichi;Kikumori, Toyone;Kodera, Yasuhiro
背景年龄是分化型甲状腺癌（DTC）复发的一个预后因素，可能与放射性碘（RAI）非亲合力有关。分子靶向药物（MTD）的适应症目前仅限于RAI难治性DTC。证明RAI的难治性，主要表现为RAI非亲合力，可能是老年患者引入MTD的障碍。本研究旨在评估年龄和组织学类型对DTC复发病灶RAI亲和力的影响。（189例经典型甲状腺乳头状癌[cPTC]患者，8例滤泡型甲状腺乳头状癌患者，61例滤泡型甲状腺癌患者），回顾性研究了2004年至2013年期间在我们机构接受首次RAI全身扫描的复发性DTC。放射性碘摄取通过诊断性RAI全身扫描中转移病灶的可见摄取来确定。
Background Age is a prognostic factor for recurrent differentiated thyroid carcinoma (DTC) and may be related to radioactive iodine (RAI) nonavidity. Indications for molecular-targeted drugs (MTDs) are currently limited to RAI-refractory DTC. Demonstrating refractoriness to RAI, mainly indicated by RAI nonavidity, may be a barrier to the introduction of MTDs for elderly patients. The present study was conducted to evaluate the impact of age and histological type on the RAI avidity of recurrent lesions of DTC.Methods Two hundred fifty-eight patients (189 patients with classic papillary thyroid carcinoma [cPTC], 8 patients with follicular variant of papillary thyroid carcinoma, and 61 patients with follicular thyroid carcinoma), who underwent their first RAI whole-body scanning for recurrent DTC at our institution between 2004 and 2013, were retrospectively studied. Radioactive iodine uptake was determined by visible uptake by metastatic lesion(s) in a diagnostic RAI-whole-body scan.Results The prevalence of RAI-avid lung metastases in cPTC indicated a significant, inverse correlation with age (