Apolipoprotein E and functional recovery from brain injury following postacute rehabilitation
Apolipoprotein E and functional recovery from brain injury following postacute rehabilitation
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DOI：
10.1212/wnl.55.10.1536
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发表时间：
2000-11-28
期刊：
影响因子：
9.9
通讯作者：
Marder, K
中科院分区：
文献类型：
--
作者：
Lichtman, SW;Seliger, G;Marder, K
目的：APOE epsilon4 与迟发性家族性和散发性 AD 以及头部损伤恢复延迟有关。作者研究了头部损伤患者的功能恢复与 APOE 等位基因之间的关系。方法：对已在 Helen Hayes 医院完成急性神经康复计划的 31 名头部损伤患者进行 APOE epsilon4 的存在评估，并根据功能独立测量 (FIM) 评估康复情况。结果：协方差分析（使用昏迷天数作为协变量来控制患有和不患有 APOE epsilon4 的受试者之间初始损伤严重程度的差异）显示，患有和不患有 APOE epsilon4 的受试者之间的总 FIM 和运动 FIM 评分存在显着差异。具体而言，APOE epsilon4 携带者的总 FIM（df = 30；F = 3.341；p = 0.05）和运动 FIM（df = 30；F = 4.189；p = 0.026）得分较低，FIM 的认知部分没有发现差异。结论：数据表明，脂蛋白 APOE epsilon4 的存在会对创伤性脑损伤幸存者的康复结果产生不利影响。
Objective: APOE epsilon4 has been associated with late-onset familial and sporadic AD and delayed recovery from head injury. The authors examined the relationship between functional recovery of patients with head injury and the APOE alleles. Methods: Thirty-one patients with head injury who had completed the Acute Neurorehabilitation Program at Helen Hayes Hospital were evaluated for presence of APOE epsilon4 and assessed for recovery based on Functional Independence Measures (FIM). Results: Analysis of covariance (using coma days as the covariate to control for differences in initial severity of injury between subjects with and without APOE epsilon4) revealed a significant difference for both total FIM and motor FIM scores between the subjects with and without APOE epsilon4. Specifically, there were lower scores for total FIM (df = 30; F = 3.341; p = 0.05) and motor FIM (df = 30; F = 4.189; p = 0.026) in APOE epsilon4 carriers, No difference was found for the cognitive portion of the FIM. Conclusions: The data suggest that the presence of the lipoprotein APOE epsilon4 adversely affects rehabilitation outcome for traumatic brain injury survivors.