Determination of Tetracyclines in Chicken by Dispersive Solid Phase Microextraction Based on Metal-Organic Frameworks/Molecularly Imprinted Nano-polymer and Ultra Performance Liquid Chromatography
Determination of Tetracyclines in Chicken by Dispersive Solid Phase Microextraction Based on Metal-Organic Frameworks/Molecularly Imprinted Nano-polymer and Ultra Performance Liquid Chromatography
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金属有机骨架/分子印迹纳米聚合物分散固相微萃取超高效液相色谱法测定鸡肉中的四环素类药物
DOI：
10.1007/s12161-020-01744-0
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发表时间：
2020-03-16
影响因子：
2.9
通讯作者：
Wang, Jian Ping
中科院分区：
文献类型：
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作者：
Ma, Ning;Feng, Cheng;Wang, Jian Ping
本研究将米诺环素分子印迹纳米聚合物聚合在金属有机骨架材料表面，合成了一种新型复合材料。以该复合物为吸附剂，建立了分散固相微萃取方法，提取鸡肉中7种四环素类药物，并用超高效液相色谱法测定。该复合材料对 7 种四环素具有高吸附容量（2200–3000 ng/mg）和高回收率（>92%），并且可重复使用 8 次。由于富集因子较高 (18–37)，7 种药物的检出限在 0.2–0.6 ng/g 范围内，定量限在 0.5–2.0 ng/g 范围内。标准强化空白鸡肌肉样品中 7 种药物的回收率在 69.6-94.7% 范围内。因此，该方法可作为肉类中四环素类残留多重检测的实用工具。
In this study, the molecularly imprinted nano-polymer of minocycline was polymerized on the surface of a metal organic framework material to synthesize a novel composite. This composite was used as absorbent to develop a dispersive solid phase microextraction method for extraction of 7 tetracyclines in chicken muscle followed by determination with ultra performance liquid chromatography. The composite achieved high absorption capacities (2200–3000 ng/mg) and high recoveries (> 92%) for the 7 tetracyclines, and could be reused for 8 times. Due to the high enrichment factors (18–37), the limits of detection for the 7 drugs were in the range of 0.2–0.6 ng/g, and the limits of quantification were in the range of 0.5–2.0 ng/g. The recoveries of the 7 drugs from standard-fortified blank chicken muscle sample were in the range of 69.6–94.7%. Therefore, this method could be used as a practical tool for multi-detection of the residues of tetracyclines in meat.