Roles of Presynaptic NMDA Receptors in Neurotransmission and Plasticity.
Roles of Presynaptic NMDA Receptors in Neurotransmission and Plasticity.
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DOI：
10.1016/j.tins.2015.11.001
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发表时间：
2016-01
影响因子：
15.9
通讯作者：
Paulsen O
中科院分区：
文献类型：
--
作者：
Banerjee A;Larsen RS;Philpot BD;Paulsen O
突触前NMDA受体（preNMDARs）在兴奋性神经传递和突触可塑性中起关键作用。它们促进突触前神经递质释放和调节机制，控制突触成熟和可塑性在大脑发育的形成时期。人们对preNMDARs在经验依赖性突触和电路特异性计算中的作用越来越了解。在这篇综述中，我们总结了关于preNMDARs的区室特异性表达和功能的最新认识，以及它们如何参与突触特异性和电路水平的信息处理。
Presynaptic NMDA receptors (preNMDARs) play pivotal roles in excitatory neurotransmission and synaptic plasticity. They facilitate presynaptic neurotransmitter release and modulate mechanisms controlling synaptic maturation and plasticity during formative periods of brain development. There is an increasing understanding of the roles of preNMDARs in experience-dependent synaptic and circuit-specific computation. In this review, we summarize the latest understanding of compartment-specific expression and function of preNMDARs, and how they contribute to synapse-specific and circuit-level information processing.