Evaluation of Seasonal Variations of the Structure and Anti-inflammatory Activity of Sulfated Polysaccharides Extracted from the Red Alga Delesseria sanguinea (Hudson) Lamouroux (Ceramiales, Delesseriaceae)
Evaluation of Seasonal Variations of the Structure and Anti-inflammatory Activity of Sulfated Polysaccharides Extracted from the Red Alga Delesseria sanguinea (Hudson) Lamouroux (Ceramiales, Delesseriaceae)
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DOI：
10.1021/bm8014158
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发表时间：
2009-05-01
影响因子：
6.2
通讯作者：
Alban, Susanne
中科院分区：
文献类型：
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作者：
Gruenewald, Niels;Groth, Inken;Alban, Susanne
血缘小球藻Delesseria sanguina(Hudson)Lamouroux含有具有抗炎作用的硫酸盐多糖(D.S.-SP)。事实证明，这种红色的大型藻类主要栖息在波罗的海西南部的一个人工珊瑚礁上。它的经济利用的一个重要方面是获得可重复性的D.S.-SP。这项研究的目的是评估D.S.-SP的季节变化；为此，在一年的时间里每月收获一批藻类。分离的D.S.-SP的结构和药理特征表明，优化和标准化的水提物(85℃)可产生可重复性的产物，其弹性蛋白酶和透明质酸酶抑制活性没有任何明显的季节性变化。除了产量(从4月份的17.9%到9月份的6.12%)外，只有D.S.-SP批次的葡萄糖含量随着季节的变化而变化(4月份，7.48%+/-1.00%，9月份，22.8%+/-1.2%)，这是由于某些类淀粉葡聚糖的共提取。原则上全年都可以收获藻类物质，但最佳收获时间是春季。
Delesseria sanguinea (Hudson) Lamouroux was shown to contain sulfated polysaccharides (D.s.-SP) with anti-inflammatory effects. This red macroalga turned out to dominantly populate an artificial reef in the southwestern Baltic Sea. An important aspect for its economical utilization is to obtain D.s.-SP in a reproducible quality. The aim of the study was to evaluate the seasonal variability of D.s.-SP; for this, algae batches were harvested monthly over the period of one year. Structural and pharmacological characterization of the isolated D.s.-SP showed that an optimized and standardized aqueous extraction (85 degrees C) leads to reproducible products without any significant seasonal variations of their elastase and hyaluronidase inhibitory activities. Besides the yields (from 17.9% in April to 6.12% in September), only the glucose content of the D.s.-SP batches seasonally varied (April, 7.48% +/- 1.00%, September, 22.8% +/- 1.2%) due to certain coextraction of starch-like glucans. In principle, algae material can be harvested throughout the year, but the optimum harvesting time is in spring.