Myosin binding protein H-like (MYBPHL): a promising biomarker to predict atrial damage
Myosin binding protein H-like (MYBPHL): a promising biomarker to predict atrial damage
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DOI：
10.1038/s41598-019-46123-w
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发表时间：
2019-07-10
影响因子：
4.6
通讯作者：
Krane, Markus
中科院分区：
文献类型：
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作者：
Lahm, Harald;Dressen, Martina;Krane, Markus
肌球蛋白结合蛋白h样（MYBPHL）是心房组织中与肌丝结构相关的一种蛋白。该蛋白存在于两个异构体中，除了异构体2中缺失了23个氨基酸外，它们具有相同的氨基酸序列。本研究发现MYBPHL在心房组织中优先表达。异构体2的表达几乎完全局限于心房，在心室、乳腺内动脉和骨骼肌中几乎检测不到。在低温或射频消融引起心房损伤后，MYBPHL以一种时间依赖性的方式快速特异性释放到外周循环中。患者到达重症监护病房24小时后，血浆MYBPHL浓度仍显著升高。此外，记录的MYBPHL值与已建立的生物标志物CK-MB值密切相关。相比之下，在接受主动脉瓣置换术或经导管主动脉瓣植入术的患者中，MYBPHL水平的增加并不明显。在这些患者中，这些值几乎保持不变，从未超过健康对照者血浆中的浓度。我们的研究结果表明，MYBPHL可以作为一种精确可靠的生物标志物来特异性预测心房心肌损伤。
Myosin binding protein H-like (MYBPHL) is a protein associated with myofilament structures in atrial tissue. The protein exists in two isoforms that share an identical amino acid sequence except for a deletion of 23 amino acids in isoform 2. In this study, MYBPHL was found to be expressed preferentially in atrial tissue. The expression of isoform 2 was almost exclusively restricted to the atria and barely detectable in the ventricle, arteria mammaria interna, and skeletal muscle. After atrial damage induced by cryo-or radiofrequency ablation, MYBPHL was rapidly and specifically released into the peripheral circulation in a time-dependent manner. The plasma MYBPHL concentration remained substantially elevated up to 24 hours after the arrival of patients at the intensive care unit. In addition, the recorded MYBPHL values were strongly correlated with those of the established biomarker CK-MB. In contrast, an increase in MYBPHL levels was not evident in patients undergoing aortic valve replacement or transcatheter aortic valve implantation. In these patients, the values remained virtually constant and never exceeded the concentration in the plasma of healthy controls. Our findings suggest that MYBPHL can be used as a precise and reliable biomarker to specifically predict atrial myocardial damage.