Preparation of Fluorinated Tetrahydropyrans and Piperidines using a New Nucleophilic Fluorination Reagent DMPU/HF.
Preparation of Fluorinated Tetrahydropyrans and Piperidines using a New Nucleophilic Fluorination Reagent DMPU/HF.
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使用新型亲核氟化试剂 DMPU/HF 制备氟化四氢吡喃和哌啶
DOI：
10.1021/acs.orglett.5b01919
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发表时间：
2015-08-21
期刊：
影响因子：
5.2
通讯作者：
Xu B
中科院分区：
文献类型：
--
作者：
Okoromoba OE;Hammond GB;Xu B
DMPU/HF（HF 含量 65 wt%/wt）是一种理想的亲核氟化试剂，用于通过氟-Prins 反应非对映选择性合成取代的 4-氟四氢吡喃和 4-氟哌啶。与吡啶/HF 等经典亲核氟化试剂相比，DMPU/HF 具有更高的产率和更好的非对映选择性。
DMPU/HF (HF content 65 wt %/wt) is an ideal nucleophilic fluorination reagent for the diastereoselective synthesis of substituted 4-fluorotetrahydropyrans and 4-fluoropiperidines via a fluoro-Prins reaction. When compared to classical nucleophilic fluorination reagents like pyridine/HF, DMPU/HF gives both higher yields and better diastereoselectivity.