The role of oxytocin in social bonding, stress regulation and mental health: An update on the moderating effects of context and interindividual differences
The role of oxytocin in social bonding, stress regulation and mental health: An update on the moderating effects of context and interindividual differences
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DOI：
10.1016/j.psyneuen.2013.06.019
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发表时间：
2013-09-01
影响因子：
3.7
通讯作者：
van Zuiden, Mirjam
中科院分区：
文献类型：
--
作者：
Olff, Miranda;Frijling, Jessie L.;van Zuiden, Mirjam
在这篇综述中，我们总结了2012年9月在纽约举行的第42届国际心理神经内分泌学会年会上发表的五项研究的结果和结论。催产素的管理已受到越来越多的关注，因为它在促进积极的社会行为和压力调节的作用，以及它作为一种治疗干预，解决精神疾病的各个方面的潜力。然而，人们注意到，观察到的效果并不是一律有益的。在本文中，我们提出了五个新的研究，每个结论是，上下文和个体间的因素温和的催产素的影响，以及外周催产素水平。这些研究结果是根据最近的想法，催产素管理可能会增加敏感性的社会显着性线索，这些线索的解释可能会受到上下文（即存在的陌生人与朋友）或个体间的因素（即性别，依恋风格，或精神症状的存在）。当环境中的社会线索被解释为“安全”时，催产素可能会促进亲社会性，但当社会线索被解释为“不安全”时，催产素可能会促进更多的防御性，实际上，“反社会”的情绪和行为。同样，催产素似乎促进了长期倾向于以不确定和/或消极的方式看待社会环境的个体的这种激动倾向（例如，患有边缘型人格障碍、严重依恋焦虑和/或童年虐待的人）。总之，在临床前动物、健康人和患者样本中的这些研究进一步加强了在试图理解催产素作为社会结合和压力调节过程的生物基质的作用时，以及在研究催产素给药的作用时，特别是在患有精神障碍（风险增加）的患者中，考虑背景和个体间因素的重要性。(C)2013爱思唯尔有限公司保留所有权利。
In this review we summarize the results and conclusions of five studies as presented in a symposium at the 42nd annual meeting of the International Society for Psychoneuroendocrinology, in New York in September 2012. Oxytocin administration has received increasing attention for its role in promoting positive social behavior and stress regulation, and its potential as a therapeutic intervention for addressing various aspects of psychiatric disorders. However, it has been noted that the observed effects are not uniformly beneficial. In this paper we present five new studies each concluding that contextual and interindividual factors moderate the effects of oxytocin, as well as peripheral oxytocin levels. These findings are in accordance with the recent idea that oxytocin administration may increase sensitivity to social salience cues and that the interpretation of these cues may be influenced by contextual (i.e. presence of a stranger versus friend) or interindividual factors (i.e. sex, attachment style, or the presence of psychiatric symptoms). When social cues in the environment are interpreted as "safe" oxytocin may promote prosociality but when the social cues are interpreted as "unsafe" oxytocin may promote more defensive and, in effect, "anti-social" emotions and behaviors. Likewise, oxytocin appears to promote such agonistic tendencies in individuals who are chronically pre-disposed to view the social milieu in uncertain and/or in negative terms (e.g., those with borderline personality disorder, severe attachment anxiety and/or childhood maltreatment). In all, these studies in pre-clinical animal, healthy humans and patients samples further reinforce the importance of considering both contextual and interindividual factors when trying to understand the role of oxytocin as a biological substrate underlying social bonding and stress regulatory processes and when studying the effects of oxytocin administration in particular in patients with (increased risk for) psychiatric disorders. (C) 2013 Elsevier Ltd. All rights reserved.