Surface markers for chondrogenic determination: a highlight of synovium-derived stem cells.
Surface markers for chondrogenic determination: a highlight of synovium-derived stem cells.
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作者：
Campbell DD;Pei M
软骨组织工程是再生医学中一个很有前途的领域，可以为患有退行性软骨疾病的人们提供实质性的缓解。目前的研究表明，滑膜来源的间充质干细胞 (MSC) 具有最大的软骨形成潜力，且具有最小的肥厚分化。这些干细胞具有分化成与间充质组织相关的多种细胞谱系的能力；然而，有证据表明细胞表面标记比其他分化命运具有更大的软骨形成潜力。本综述将查阅相关文献，总结所测试的滑膜源性干细胞（SDSC）表面标记物的软骨分化能力，并讨论可能具有潜力但需要进一步研究的各种其他标记物。有了这些信息，开发 SDSC 筛选系统就有潜在的临床益处，该系统将产生尽可能健康的关节软骨。
Cartilage tissue engineering is a promising field in regenerative medicine that can provide substantial relief to people suffering from degenerative cartilage disease. Current research shows the greatest chondrogenic potential for healthy articular cartilage growth with minimal hypertrophic differentiation to be from mesenchymal stem cells (MSCs) of synovial origin. These stem cells have the capacity for differentiation into multiple cell lineages related to mesenchymal tissue; however, evidence exists for cell surface markers that specify a greater potential for chondrogenesis than other differentiation fates. This review will examine relevant literature to summarize the chondrogenic differentiation capacities of tested synovium-derived stem cell (SDSC) surface markers, along with a discussion about various other markers that may hold potential, yet require further investigation. With this information, a potential clinical benefit exists to develop a screening system for SDSCs that will produce the healthiest articular cartilage possible.