Perinatal characteristics in relation to incidence of and mortality from prostate cancer
Perinatal characteristics in relation to incidence of and mortality from prostate cancer
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DOI：
10.1136/bmj.313.7053.337
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发表时间：
1996-08-10
影响因子：
105.7
通讯作者：
Trichopoulos, D
中科院分区：
文献类型：
--
作者：
Ekbom, A;Hsieh, CC;Trichopoulos, D
目的 - 检验导致前列腺癌发病和死亡的因素可能在子宫内起作用的假设。针对 1874 年至 1946 年在一家医院出生的单身男性进行设计匹配病例对照研究。地点 - 乌普萨拉大学医院。受试者 - 250 名前列腺癌患者和 691 名对照者，其中包括 80 名死于前列腺癌的患者及其 196 名匹配对照者。主要结果指标 - 母亲初潮时的年龄，产次、先兆子痫或产前子痫、分娩年龄和社会经济状况；病例或对照的出生身长和体重、胎盘重量、胎龄引起的早产以及是否存在黄疸。 结果 - 先兆子痫（比值比 0，95% 置信区间 0 至 0.71）和早产（0.31、0.09 至 1.04）均与前列腺癌的发病率呈负相关。在足月出生的受试者中，胎盘重量、出生体重和体重指数（体重/身高（3））与前列腺癌发病率呈非显着正相关，与死亡率呈较强相关性。结论——可能与妊娠激素和其他生长因子相关的产前暴露在前列腺癌发生中很重要，并影响这种癌症的自然病程和发生。
Objective-To test the hypothesis that factors causing morbidity and mortality from prostate cancer may operate in utero.Design-Matched case-control study of singleton men born between 1874 and 1946 at one hospital.Setting-Uppsala University Hospital.Subjects-250 patients with prostate cancer and 691 controls, including 80 patients who died from prostate cancer and their 196 matched controls.Main outcome measures-Mother's age at menarche, parity, pre-eclampsia or eclampsia before delivery, age at delivery and socioeconomic status; case or control's birth length and weight, placental weight, prematurity derived from gestational age, and presence of jaundice.Results-Both pre-eclampsia (odds ratio 0, 95% confidence interval 0 to 0.71) and prematurity (0.31, 0.09 to 1.04) were inversely associated with incidence of prostate cancer. Among subjects born full term, placental weight, birth weight, and ponderal index (weight/height(3)) showed non-significant positive associations with prostate cancer incidence, and stronger associations with mortality.Conclusion-Prenatal exposures that are likely correlates of pregnancy hormones and other growth factors are important in prostate carcinogenesis and influence the natural course as well as the occurrence of this cancer.