Binary mixed micelles of chiral sodium undecenyl leucinate and achiral sodium undecenyl sulfate: I. Characterization and application as pseudostationary phases in micellar electrokinetic chromatography.
Binary mixed micelles of chiral sodium undecenyl leucinate and achiral sodium undecenyl sulfate: I. Characterization and application as pseudostationary phases in micellar electrokinetic chromatography.
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手性十一碳烯基亮氨酸钠和非手性十一碳烯基硫酸钠的二元混合胶束：I.作为胶束电动色谱中的假固定相的表征和应用。
DOI：
10.1016/j.chroma.2009.11.023
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Akbay,Cevdet
中科院分区：
文献类型：
--
作者：
Ahlstrom,DavidM;Hoyos,YatzkaM;Arslan,Hakan;Akbay,Cevdet
制备了10-十一碳烯基硫酸钠（SUS）、10-十一碳烯基亮氨酸钠（SUL）及其不同摩尔比的五种不同混合胶束。采用多种分析技术测定了临界胶束浓度（CMC）、C20、γCMC、偏比容、亚甲基选择性、迁移率和洗脱窗口。这些表面活性剂系统，然后评价作为胶束电动色谱（MEKC）的新型假固定相。十二烷基硫酸钠（SDS）作为MEKC中常用的假固定相也进行了评价。SUS和SUL的CMC值分别为26和16 mM，而混合表面活性剂的CMC被发现与SUL的CMC非常相似。随着SUL浓度的增加，混合胶束中的C_（20）值急剧下降。随着SUL含量的增加，亚甲基选择性逐渐增加，使二元混合表面活性剂的疏水性增强。线性溶剂化能关系（LSER）和转移自由能研究也被应用于预测表面活性剂体系之间的选择性差异。表面活性剂体系的内聚性和氢键酸性特征被认为对选择性和MEKC保留率具有最显著的影响。SUS和SDS的氢键贡献能力最强，SUL的氢键贡献能力最弱。碱性、与溶质的n-和π-电子的相互作用以及偶极/极化率是所研究的表面活性剂体系的LSER模型中最不显著的因素。在每个表面活性剂体系中的选定的官能团的转移自由能也进行了计算，发现是在良好的协议与激光扫描电子显微镜数据。
Sodium 10-undecenyl sulfate (SUS), sodium 10-undecenyl leucinate (SUL) and their five different mixed micelles at varied percent mole ratios were prepared. The critical micelle concentration (CMC), C20, γCMC, partial specific volume, methylene group selectivity, mobilities and elution window were determined using a variety of analytical techniques. These surfactant systems were then evaluated as novel pseudostationary phases in micellar electrokinetic chromatography (MEKC). As a commonly used pseudostationary phase in MEKC, sodium dodecyl sulfate (SDS) was also evaluated. The CMC values of SUS and SUL were found to be 26 and 16mM, respectively, whereas the CMC of mixed surfactants was found to be very similar to that of SUL. The C20values decreased dramatically as the concentration of SUL is increased in the mixed micelle. An increase in SUL content gradually increased the methylene group selectivity making the binary mixed surfactants more hydrophobic. Linear solvation energy relationships (LSERs) and free energy of transfer studies were also applied to predict the selectivity differences between the surfactant systems. The cohesiveness and the hydrogen bond acidic character of the surfactant systems were found to have the most significant influence on selectivity and MEKC retention. The SUS and SDS showed the strongest while SUL showed the weakest hydrogen bond donating capacity. The basicity, interaction with n and π-electrons of the solute and dipolarity/polarizability were the least significant factors in LSER model for the surfactant systems studied. Free energies of transfer of selected functional groups in each surfactant systems were also calculated and found to be in good agreement with the LSER data.