ETHANOL INCREASES PLASMA VASOPRESSIN SHORTLY AFTER INTRAPERITONEAL INJECTION IN RATS
ETHANOL INCREASES PLASMA VASOPRESSIN SHORTLY AFTER INTRAPERITONEAL INJECTION IN RATS
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DOI：
10.1016/0024-3205(85)90592-2
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发表时间：
1985-01-01
期刊：
影响因子：
6.1
通讯作者：
GREIDANUS, TBV
中科院分区：
文献类型：
--
作者：
COLBERN, DL;TENHAAF, J;GREIDANUS, TBV
在大鼠中，乙醇通常被认为可以抑制加压素 (VP) 释放到外周循环中。这一结论的主要证据是间接的。放射免疫测定法用于测量腹腔注射后 5 或 60 分钟断头的大鼠血浆中的 VP。注射乙醇(2.0 g/kg)。治疗 60 分钟后 VP 水平下降，证实了乙醇抑制 VP 释放的流行观点。放射免疫分析技术显示，注射乙醇后不久，VP 的释放明显受到刺激。
In rats, ethanol has generally been thought to inhibit vasopressin (VP) release into the peripheral circulation; the primary evidence for this conclusion has been indirect. Radioimmunoassay was used to measure VP in the plasma of rats decapitated 5 or 60 min after i.p. injection of ethanol (2.0 g/kg). Confirming the popular notion that ethanol inhibits VP release, VP levels were decreased 60 min after treatment. Radioimmunoassay technique revealed that VP release is markedly stimulated shortly after an injection of ethanol.