Design of an Injectable in Situ Gelation Biomaterials for Vitreous Substitute
Design of an Injectable in Situ Gelation Biomaterials for Vitreous Substitute
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DOI：
10.1021/bm201012f
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发表时间：
2011-11-01
影响因子：
6.2
通讯作者：
Tsujinaka, Hiroki
中科院分区：
文献类型：
--
作者：
Annaka, Masahiko;Mortensen, Kell;Tsujinaka, Hiroki
为了使生物材料的物理性质适应其生物功能，自然界开发了各种具有出色物理行为的聚合物。一个例子是玻璃体，其是重要的眼内元件，不仅因为其光学和机械性能，而且还因为其在影响邻近组织并最终影响整个眼睛的病症的发病机制和治疗中的重要作用。在这里，我们报告了一种新的生物相容性材料，可注射玻璃体替代物，由热敏两亲聚合物，这是能够形成透明的凝胶在玻璃体腔。它无毒，为视网膜提供足够的支持，并允许光线到达眼睛后部的感觉元件。两亲性聚合物通过组装形成高度互连的疏水域而表现出机械稳定性，这导致网络结构的构成。
To adapt the physical properties of living materials to their biological function, nature developed various types of polymers with outstanding physical behavior. One example is the vitreous body, which is important intraocular elements not only because of its optical and mechanical performances, but also due to its important role in the pathogenesis and treatment of conditions affecting adjacent tissues and eventually the whole eye. Here, we report a novel biocompatible material for injectable vitreous substitute, composed of thermosensitive amphiphilic polymer, which is capable of forming a transparent gel in the vitreous cavity. It is nontoxic, provides adequate support for the retina, and allows light to reach the sensory elements at the back of the eye. The amphiphilic polymer exhibits mechanical stability by assembling to form highly interconnected hydrophobic domains, which leads to the constitution of a network structure.