Embryo loss pattern is predominant in miscarriages with normal chromosome karyotype among women with repeated miscarriage
Embryo loss pattern is predominant in miscarriages with normal chromosome karyotype among women with repeated miscarriage
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DOI：
10.1093/humrep/deh451
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发表时间：
2004-11-01
影响因子：
6.1
通讯作者：
Minakami, H
中科院分区：
文献类型：
--
作者：
Morikawa, M;Yamada, H;Minakami, H
目的：本研究的目的是根据胎儿染色体核型和反复流产 (RM) 的病因来评估反复流产 (RM) 妇女的妊娠丢失模式。方法：本队列研究对168例流产胎儿染色体核型进行了调查。对有两次或以上连续流产史的 RM 妇女的 75 名流产者和之前怀孕但没有 RM 史但以活产结束的对照妇女的 93 名流产者的妊娠损失模式进行了比较。通过连续超声检查，胚胎丢失（EL）定义为确定胎儿热运动之前的流产，胎儿丢失（FL）定义为确定胎儿热运动之后的流产。 EL率计算为EL/(EL+FL)。结果：RM女性（n=42）中核型正常流产的EL率（66.7%）较高（P
Objective: The aim of this study was to assess pregnancy loss patterns in women with repeated miscarriage (RM), according to fetal chromosome karyotypes and aetiologies of RM. Methods: In this cohort study, 168 fetal chromosome karyotypes of miscarriages were investigated. The pregnancy loss patterns were compared between 75 miscarriages from RM women who had a history of two or more consecutive miscarriages and 93 miscarriages from control women whose previous pregnancies ended in live births without a history of RM. By serial ultrasonography, embryo loss (EL) was defined as miscarriage before fetal heat movement was identified and fetal loss (FL) as miscarriage after fetal heat movement was identified. The EL rate was calculated as EL/(EL+FL). Results: The EL rate (66.7%) in miscarriages with normal karyotypes among RM women (n=42) was higher (P