Antigenic and functional differences in adhesion of Plasmodium falciparum-infected erythrocytes to human and bovine CD36.
Antigenic and functional differences in adhesion of Plasmodium falciparum-infected erythrocytes to human and bovine CD36.
复制标题
恶性疟原虫感染的红细胞与人和牛 CD36 粘附的抗原和功能差异。
DOI：
10.1128/iai.61.5.2229-2232.1993
复制
发表时间：
1993
影响因子：
3.1
通讯作者：
Greenwalt,DE
中科院分区：
文献类型：
--
作者：
Ockenhouse,CF;Tandon,NN;Jamieson,GA;Greenwalt,DE
恶性疟原虫感染的红细胞（PRBC）对微血管内皮的细胞粘附部分是由寄生虫衍生的红细胞表面配体和人CD 36上的特异性结合位点之间的特异性相互作用介导的。我们描述了选择增加粘附PRBC牛CD 36和证明PRBC和牛CD 36之间的分子相互作用是独立的和不同的OKM 5/8单克隆抗体表位，阻止PRBC-人CD 36结合。
Cytoadherence by Plasmodium falciparum-infected erythrocytes (PRBC) to microvascular endothelium is, in part, mediated by the specific interaction between a parasite-derived erythrocyte surface ligand and a specific binding site on human CD36. We describe the selection for increased adhesion of PRBC to bovine CD36 and demonstrate that the molecular interaction between PRBC and bovine CD36 is independent of and distinct from the OKM5/8 monoclonal antibody epitopes which block PRBC-human CD36 binding.