Total oxidative stress and antioxidant status in patients with carpal tunnel syndrome
Total oxidative stress and antioxidant status in patients with carpal tunnel syndrome
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DOI：
10.1179/1351000212y.0000000027
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发表时间：
2012-11-01
期刊：
影响因子：
3.8
通讯作者：
Kesiktas, Fatma Nur
中科院分区：
文献类型：
--
作者：
Demirkol, Ahmet;Uludag, Murat;Kesiktas, Fatma Nur
目的：腕管综合征（CTS）的研究支持缺血引起的变化，而不是屈肌腱滑膜炎症。方法：对43例CTS患者（男5例，女38例，共81只手）进行了全身检查和电生理检查，并对其总抗氧化状态（TAS）、总氧化应激（TOS）和氧化应激指数（OSI）进行了研究。结果：38例（88%）患者出现双侧CTS，5例出现单侧CTS，平均年龄43.30 ± 10.49岁。所有患者均累及优势手。平均症状持续时间为30.9个月（范围，5-67个月）。CTS患者的TAS显著低于对照组（1.01 +/- 0.14 vs. 1.11 +/- 0.20 mmol Trolox当量/ l），（P = 0.008）。CTS患者的TOS和OSI显著高于对照组（15.60 +/- 7.03 vs. 11.86 +/- 2.18 μ mol H2 O2 equiv.结论：CTS患者存在氧化应激和抗氧化防御功能的改变。TOS和OSI增加和TAS降低可能通过腱滑膜和正中神经的信号模式紊乱而刺激纤维化。这些过程可能在CTS的发生和发展中起一定作用。
Objectives: Studies in the carpal tunnel syndrome (CTS) are supported ischemia-induced changes rather than inflammation of the flexor tenosynovium. In this study, total antioxidant status (TAS), total oxidative stress (TOS) and oxidative stress index (OSI) in patients with CTS has been investigated.Methods: Forty-three patients (38 female and 5 male, 81 hands in total) diagnosed as CTS after the physical examination and electrophysiological findings included in study. The mean age of patients was 43.30 +/- 10.49 years.Results: Bilateral CTS in 38 (88%) patients and unilateral CTS in five patients were detected. Dominant hand was involved in all patients. The mean symptoms duration was 30.9 months (range, 5-67 months). TAS in patients with CTS was significantly lower compared with control (1.01 +/- 0.14 versus 1.11 +/- 0.20 mmol Trolox equiv./l), (P = 0.008). TOS and OSI in patients with CTS were significant higher compared with control (15.60 +/- 7.03 versus 11.86 +/- 2.18 mu mol H2O2 equiv./l and 1.57 +/- 0.72 versus 1.09 +/- 0.28), (respectively P = 0.002 and < 0.001).Conclusion: This study shows that there is a change in the oxidative stress and antioxidant defences in patients with CTS. Increased TOS and OSI and decreased TAS might be stimulate fibrosis through disturbed signaling pattern in the tenosynovium and median nerve. These processes might play a role in occurrence and progression of CTS.