PROSPECTIVE-STUDY OF INTRAVESICAL DIMETHYLSULFOXIDE IN TREATMENT OF SUSPECTED EARLY INTERSTITIAL CYSTITIS
PROSPECTIVE-STUDY OF INTRAVESICAL DIMETHYLSULFOXIDE IN TREATMENT OF SUSPECTED EARLY INTERSTITIAL CYSTITIS
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DOI：
10.1016/0090-4295(81)90489-1
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发表时间：
1981-01-01
期刊：
影响因子：
2.1
通讯作者：
FOWLER, JE
中科院分区：
文献类型：
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作者：
FOWLER, JE
在一项前瞻性研究中，研究了二甲基亚砜(DMSO)膀胱内灌注治疗可疑早期间质性膀胱炎的疗效。在接受治疗的20例患者中，3例症状完全缓解，16例症状部分缓解，1例症状无改善。仅4例患者治疗后功能性膀胱容量增加25%。在16名经历症状缓解并接受随访的患者中。4个月，14例持续缓解(平均随访11个月)。2例缓解不持久。临床上明显的毒性很小，但在治疗过程中偶尔会观察到血清乳酸脱氢酶的一过性升高。DMSO似乎对精心挑选的疑似早期间质性膀胱炎患者的治疗是有用的。
The efficacy of intravesical instillations of dimethyl sulfoxide (DMSO) in the treatment of suspected early interstitial cystitis was investigated in a prospective study. Among 20 patients treated, complete symptomatic remissions were achieved in 3, partial symptomatic remissions were achieved in 16 and 1 had no symptomatic improvement. Functional bladder capacities after treatment were increased by > 25% in only 4 cases. Among 16 patients who experienced symptomatic remissions and who were followed for .gtoreq. 4 mo., 14 had sustained remissions (mean follow-up 11 mo.) and 2 had unsustained remissions. Clinically apparent toxicity was minimal but transient elevation of the serum lactic dehydrogenase was occasionally observed during treatment. DMSO appears to be useful in the management of carefully selected patients with suspected early interstitial cystitis.