Primary endodermal sinus tumor of the omentum
Primary endodermal sinus tumor of the omentum
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DOI：
10.1006/gyno.1998.5268
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发表时间：
1999-03-01
影响因子：
4.7
通讯作者：
Lee, HP
中科院分区：
文献类型：
--
作者：
Park, NH;Ryu, SY;Lee, HP
摘要内胚层窦瘤是一种罕见的肿瘤，通常发生于睾丸或卵巢。但角外EST是公认的，可能出现在广泛的部位，如纵隔，阴道和大脑。我们报告一例原发性网膜EST，据我们所知，这是文献中第一例网膜EST。45岁女性，有腹胀史，行全腹子宫切除术+双侧输卵管卵巢切除术+结肠下网膜切除术，并行4周期BEP（博来霉素、依托泊苷、顺铂）联合化疗。显微镜下，肿瘤表现出典型的EST模式，并进行了甲胎蛋白和细胞角蛋白染色。在10个月的随访中，她一直没有患病。根据以往的研究，减体积手术和BEP化疗作为主要治疗方法，效果良好。本文回顾了角外EST的主题，并讨论了这种肿瘤在这种罕见部位的可能组织发生。(C) 1999学术出版社。
Endodermal sinus tumor (EST) is a rare neoplasm which usually arises in the testis or ovary. But extragonadal EST is well recognized and may arise in a wide array of sites such as the mediastinum, vagina, and brain. We report a case of primary EST of the omentum and to our knowledge it is the first case of omental EST in the literature. A 45-year-old woman with a history of abdominal distension was treated with total abdominal hysterectomy with bilateral salpingo-oophorectomy and infracolic omentectomy, followed by four cycles of BEP (bleomycin, etoposide, cisplatin) combination chemotherapy. Microscopically, the tumor exhibited typical patterns of EST and stained for alpha-fetoprotein and cytokeratin. She has remained free of disease for 10 months of follow-up. According to previous studies, debulking surgery and BEP chemotherapy were used as primary therapy with good results. The subject of extragonadal EST is reviewed, and the possible histogenesis of this tumor at such a rare site is discussed. (C) 1999 Academic Press.