Dopamine derivatives from the insect Polyrhachis dives as inhibitors of ROCK1/2 and stimulators of neural stem cell proliferation
Dopamine derivatives from the insect Polyrhachis dives as inhibitors of ROCK1/2 and stimulators of neural stem cell proliferation
复制标题
来自多刺昆虫的多巴胺衍生物可作为 ROCK1/2 的抑制剂和神经干细胞增殖的刺激剂
DOI：
10.1016/j.tet.2014.09.095
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发表时间：
2014-11-18
期刊：
影响因子：
2.1
通讯作者：
Cheng, Yong-Xian
中科院分区：
文献类型：
--
作者：
Tang, Jian-Jun ab;Zhang, Li;Cheng, Yong-Xian
在中国的一些地区，金鱼被当作昆虫的食物食用。本研究从该物种中分离到新的多巴胺衍生物(+)- polyrha多巴胺A （1a）和(-)- polyrha多巴胺A (1b), (+)- polyrha多巴胺B （2a）和(-)- polyrha多巴胺B (2b)，以及polyrha多巴胺C-E（3-5）。利用光谱学和计算方法确定了这些物质的结构和立体化学性质。化合物1a、1b、2a和2b是二聚体n -乙酰基多巴胺衍生物，3是多巴胺类似物，含有不寻常的砜基团，4和5具有罕见的苯并[d]噻唑片段。测定了这些物质作为ROCK1/2抑制剂、神经干细胞（NSCs）增殖刺激剂、免疫抑制剂和抗炎剂的功能。(C) 2014 Elsevier Ltd.版权所有。
Polyrhachis dives is consumed as an insect food in some regions of China. In this study, new dopamine derivatives, (+)-polyrhadopamine A (1a) and (-)-polyrhadopamine A (1b), (+)-polyrhadopamine B (2a) and (-)-polyrhadopamine B (2b), and polyrhadopamines C-E (3-5), were isolated from this species. The structures and stereochemistry of these substances were assigned by using spectroscopic and computational methods. Compounds 1a, 1b, 2a, and 2b are dimeric N-acetyldopamine derivatives, 3 is a dopamine analog containing an unusual sulfone group, and 4 and 5 possess a rare benzo[d]thiazole moiety. The functions of these substances as ROCK1/2 inhibitors, neural stem cell (NSCs) proliferation stimulators, immunosuppressive, and anti-inflammatory agents were determined. (C) 2014 Elsevier Ltd. All rights reserved.