DQX1, an RNA-dependent ATPase homolog with a novel DEAQ box: expression pattern and genomic sequence comparison of the human and mouse genes.
DQX1, an RNA-dependent ATPase homolog with a novel DEAQ box: expression pattern and genomic sequence comparison of the human and mouse genes.
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DQX1，一种具有新型 DEAQ 盒的 RNA 依赖性 ATP 酶同源物：人类和小鼠基因的表达模式和基因组序列比较。
DOI：
10.1007/s003350020032
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Meisler,MH
中科院分区：
文献类型：
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作者：
Ji,W;Chen,F;Do,T;Do,A;Roe,BA;Meisler,MH
DQX1 是一个与 RNA 依赖性 ATP 酶相关的新基因。根据十个短蛋白基序的保守顺序和间隔，该基因被归类为 DEAD/H 家族的成员。 DQX1 的独特特征包括用 DEAQ 替换标志性 DEAH 基序以及缺少解旋酶基序。我们确定了人和小鼠DQX1的编码序列，其编码717和718个氨基酸的蛋白质，氨基酸序列同一性为84%。 3.2-kbDqx1 转录本在肌肉和肝脏中表达最高。 DQX1 位于人染色体 (Chr) 2p13 和小鼠 Chr 6 基因密集区域中的 AUP1 和 HOX11L1 之间。尽管 DQX1 位于小鼠神经肌肉突变体 mnd2 的非重组区域内，但在正常小鼠和 mnd2 突变小鼠之间没有观察到编码序列、转录本长度或转录本丰度存在差异。 DQX1 的普遍表达及其与酵母前 mRNA 加工 (Prp) 蛋白的密切系统发育关系表明其在细胞 RNA 代谢中发挥作用。
DQX1 is a novel gene related to the RNA-dependent ATPases. The gene was classified as a member of the DEAD/H family on the basis of the conserved order and spacing of ten short protein motifs. The unique features of DQX1 include replacement of the signature DEAH motif with DEAQ and the absence of the helicase motif. We determined the coding sequences of human and mouse DQX1, which encode proteins of 717 and 718 amino acids with 84% amino acid sequence identity. The 3.2-kbDqx1transcript has highest expression in muscle and liver. DQX1 is located between AUP1 and HOX11L1 in a gene-dense region of human Chromosome (Chr) 2p13 and mouse Chr 6. Although DQX1 is within the nonrecombinant region for the mouse neuromuscular mutant mnd2, no difference in coding sequence, transcript length, or transcript abundance was observed between normal mice and mnd2 mutant mice. The ubiquitous expression of DQX1 and its close phylogenetic relationship to the yeast pre-mRNA processing (Prp) proteins suggest a role in cellular RNA metabolism.