Dietary taurine potentiates polychlorinated biphenyl-induced hypercholesterolemia in rats
Dietary taurine potentiates polychlorinated biphenyl-induced hypercholesterolemia in rats
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DOI：
10.1016/s0955-2863(00)00145-5
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发表时间：
2001-02-01
影响因子：
5.6
通讯作者：
Yokogoshi, H
中科院分区：
文献类型：
--
作者：
Mochizuki, H;Oda, H;Yokogoshi, H
研究了牛磺酸对多氯联苯（PCB）饲料喂养大鼠胆固醇代谢和血清脂蛋白胆固醇分布的影响。年轻的雄性Wistar大鼠（60克）喂养的饮食含有0.2克/公斤的饮食的PCB和/或30克/公斤的饮食的牛磺酸15天。实验采用2（PCB）× 2（牛磺酸）析因设计。PCB的添加提高了血清总胆固醇和HDL胆固醇以及载脂蛋白A-I（HDL的主要载脂蛋白）的水平。同时补充牛磺酸与PCB放大了血清总胆固醇和HDL-胆固醇水平的增加。肝脏中的胆固醇和总脂质浓度显着升高的PCB的补充，和牛磺酸显着放大PCB引起的这些增加。PCB抑制肝脏胆固醇7 α-羟化酶（CYP 7A 1）基因表达，牛磺酸诱导CYP 7A 1基因表达。牛磺酸还增强了多氯联苯诱导的肝脏中苹果酸酶mRNA的升高。这些结果表明，牛磺酸增强PCB诱导的高-α-胆固醇血症，牛磺酸有增加HDL-胆固醇的作用。(C)2001 Elsevier Science Inc. All rights reserved.
The effect of dietary taurine on cholesterol metabolism and the distribution of lipoprotein-cholesterol in serum of rats fed a diet containing polychlorinated biphenyls (PCB) was examined. Young male Wistar rats (60 g) were fed diets containing 0.2 g/kg diet of PCB and/or 30 g/kg diet of taurine for 15 days. The experiment was performed as the 2 (PCB) X 2 (taurine) factorial design. The addition of PCB elevated serum levels of total- and HDL-cholesterol and apolipoprotein A-I, which is a major apolipoprotein of HDL. Simultaneous supplementation of taurine with PCB amplified the increase of the serum level of total- and HDL-cholesterol. Hepatic concentrations of cholesterol and total lipids were significantly elevated by the supplementation of PCB, and taurine significantly amplified these increases caused by PCB. PCB suppressed hepatic cholesterol 7 alpha -hydroxylase (CYP7A1) gene expression, and taurine induced CYP7A1 gene expression. Taurine also enhanced PCB-induced elevation of malic enzyme mRNA in the liver. These results suggest that taurine enhanced PCB-induced hyper-a-cholesterolemia and that taurine has a role in increasing HDL-cholesterol. (C) 2001 Elsevier Science Inc. All rights reserved.