D2 and D3 dopamine receptor affinity predicts effectiveness of antipsychotic drugs in obsessive-compulsive disorders: a metaregression analysis
D2 and D3 dopamine receptor affinity predicts effectiveness of antipsychotic drugs in obsessive-compulsive disorders: a metaregression analysis
复制标题
DOI：
10.1007/s00213-014-3516-3
复制
发表时间：
2014-09-01
影响因子：
3.4
通讯作者：
Fond, Guillaume
中科院分区：
文献类型：
--
作者：
Ducasse, Deborah;Boyer, Laurent;Fond, Guillaume
分析强迫症(OCD)临床有效的抗精神病药物与克隆的多巴胺和5-羟色胺受体亚型的结合亲和力之间的关系，以阐明单个受体亚型对药物反应的贡献。纳入12个先前分析的随机对照试验(RCT)和1个新的随机对照试验。我们使用混合效应模型进行了荟萃回归，以检验抗精神病药物的有效性和受体亲和力之间的关系。我们的研究包括13个随机对照试验(431名患者)的5个治疗臂。我们的荟萃回归结果显示，D2和D3多巴胺受体亲和力与强迫症的疗效显著相关(分别为斜率=-0.36，p=0.01；斜率=-0.50，p=0.01)，而其他多巴胺受体和5-羟色胺受体的相关性不显著。这些观察表明，增加D2和D3多巴胺受体亲和力可以增强抗精神病药物在强迫症中的有效性。
The relationship between clinically effective antipsychotic drugs in obsessive-compulsive disorders (OCD) and binding affinities to cloned dopamine and serotonin receptor subtypes was analyzed in an effort to clarify the contribution of individual receptor subtypes to medication response.Meta-analysis was used to update previous meta-analyses of effectiveness data of add-on antipsychotic drugs to selective serotonin reuptake inhibitors (SSRIs) in OCD. Twelve previously analyzed randomized controlled trials (RCTs) and one new RCT were included. We performed a metaregression using a mixed-effect model to examine the association between antipsychotic's effectiveness and receptor affinity.A total of 5 treatment arms obtained from 13 RCTs (431 patients) were included in our study. The results of our metaregression showed a significant association between D2 and D3 dopamine receptor affinities and effectiveness in OCD (respectively, slope = -0.36, p = 0.01; and slope = -0.50, p = 0.01) whereas other dopamine receptors and serotonin receptors were not significantly associated.These observations suggest that increasing D2 and D3 dopamine receptor binding affinities enhances antipsychotics' effectiveness in obsessive-compulsive disorders.