FGF-10 is a growth factor for preadipocytes in white adipose tissue.
FGF-10 is a growth factor for preadipocytes in white adipose tissue.
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FGF-10 是白色脂肪组织中前脂肪细胞的生长因子。
DOI：
10.1006/bbrc.1999.0594
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发表时间：
1999
影响因子：
3.1
通讯作者：
N. Itoh
中科院分区：
文献类型：
--
作者：
M. Yamasaki;H. Emoto;M. Konishi;T. Mikami;H. Ohuchi;K. Nakao;N. Itoh
FGF-10 是一种在模式形成过程中影响上皮细胞的间充质因子。然而，FGF-10 在成人中的表达和生理作用仍有待阐明。我们检查了多种成年大鼠组织中 FGF-10 mRNA 的表达，发现白色脂肪组织中含量最高。在白色脂肪组织中，FGF-10 mRNA 在前脂肪细胞中表达，但在成熟脂肪细胞中不表达。还检查了出生后发育期间白色脂肪组织中的表达。出生后第10天（P10）表达水平较低。然而，当白色脂肪组织生长受到刺激时，随后（P28 和 P48）大量检测到 FGF-10 mRNA。我们还检测了重组 FGF-10 对原代大鼠前脂肪细胞的活性。 FGF-10对原代前脂肪细胞表现出显着的有丝分裂活性，但不影响前脂肪细胞的分化。本文报道的 FGF-10 mRNA 表达谱和 FGF-10 活性表明 FGF-10 是白色脂肪组织中产生的独特分泌因子，可作为白色脂肪组织中前脂肪细胞的生长因子。
FGF-10 is a mesenchymal factor affecting epithelial cells during pattern formation. However, the expression and physiological role of FGF-10 in adults remains to be elucidated. We examined the expression of FGF-10 mRNA in a variety of adult rat tissues, and found to be most abundant in white adipose tissue. In white adipose tissue, FGF-10 mRNA was expressed in preadipocytes but not in mature adipocytes. The expression in white adipose tissue during postnatal development was also examined. The expression level was low at postnatal day 10 (P10). However, FGF-10 mRNA was abundantly detected later on (P28 and P48) when white adipose tissue growth was stimulated. We also examined the activity of recombinant FGF-10 for primary rat preadipocytes. FGF-10 showed significant mitogenic activity for primary preadipocytes, but did not affect the differentiation of preadipocytes. The expression profile of FGF-10 mRNA and the activity of FGF-10 reported here indicate that FGF-10, a unique secreted factor produced in white adipose tissue, acts as a growth factor for preadipocytes in white adipose tissues.
影响因子：
4.6
作者：
S. Bellusci;J. Grindley;H. Emoto;N. Itoh;B. Hogan
通讯作者：
S. Bellusci;J. Grindley;H. Emoto;N. Itoh;B. Hogan