THE PATHOGENESIS OF CLUB FOOT - A HISTOMORPHOMETRIC AND IMMUNOHISTOCHEMICAL STUDY OF FETUSES
THE PATHOGENESIS OF CLUB FOOT - A HISTOMORPHOMETRIC AND IMMUNOHISTOCHEMICAL STUDY OF FETUSES
复制标题
DOI：
10.1302/0301-620x.76b3.8175852
复制
发表时间：
1994-05-01
影响因子：
--
通讯作者：
UHTHOFF, HK
中科院分区：
文献类型：
--
作者：
FUKUHARA, K;SCHOLLMEIER, G;UHTHOFF, HK
我们研究了16个马蹄内翻足和27个正常的脚从自然流产的人类胎儿在妊娠中期和测量的长度，弹簧韧带，和斜角和距骨的大小。我们还研究了弹簧韧带的细胞特性和踝关节内侧韧带的免疫组织化学特征，使用单克隆抗体对HI型胶原蛋白，结蛋白，波形蛋白，平滑肌actin.Histomorphometric结果表明，距骨畸形不是原发性病变。组织学和免疫组织化学研究结果表明，内踝韧带的俱乐部脚的细胞和胶原纤维似乎是最早的变化的网站，因为他们已经失去了空间方向和收缩。在妊娠晚期之前的严重马蹄内翻足中，肌纤维母细胞样细胞似乎产生了类似纤维瘤病的韧带紊乱。这导致收缩，并导致典型的马蹄内翻足畸形。
We studied 16 club feet and 27 normal feet from spontaneously aborted human fetuses in the second trimester of gestation and measured the length of the spring ligament, and the declination angle and size of the talus. We also studied the cellular characteristics of the spring ligament and the immunohistochemical features of the medial ankle ligaments using monoclonal antibodies against type-HI collagen, desmin, vimentin, and smooth muscle actin.Histomorphometric results indicated that the talar deformity was not the primary lesion. Histological and immunohistochemical findings showed that the cells and collagen fibres of the medial ankle ligaments of club feet appeared to be the site of the earliest changes, in that they had lost their spatial orientation and had contracted. In severe club feet before the third trimester of gestation, myofibroblast-like cells seemed to create a disorder of the ligaments resembling fibromatosis. This led to contraction and resulted in typical club-foot deformity.