Autophagosome closure by ESCRT: Vps21/RAB5-regulated ESCRT recruitment via an Atg17-Snf7 interaction
Autophagosome closure by ESCRT: Vps21/RAB5-regulated ESCRT recruitment via an Atg17-Snf7 interaction
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ESCRT 关闭自噬体：Vps21/RAB5 通过 Atg17-Snf7 相互作用调节 ESCRT 招募
DOI：
10.1080/15548627.2019.1628547
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发表时间：
2019
期刊：
影响因子：
13.3
通讯作者：
Liang Yongheng
中科院分区：
文献类型：
--
作者：
Zhou Fan;Wu Zulin;Zhao Mengzhu;Segev Nava;Liang Yongheng
自噬/巨噬途径包括吞噬体组装结构形成、吞噬体扩张、自噬体关闭以及自噬体与溶酶体/空泡融合的连续步骤。虽然关于自噬早期和晚期重要的调节因子、因子和分子机制的信息是丰富的，但是关于AP关闭的信息是稀缺的。在2017年，我们报道了Vps 21/RAB 5 GTdR模块调节酵母中的AP关闭。在最近的一篇论文中，我们表明Vps 21通过控制Atg 17-Snf 7相互作用来调节ESCRT向AP的募集，以催化其关闭。因此，我们确定了一个调节器，一个因素，和AP关闭的重要分子机制。缩略语：美联社：自噬体; Atg：自噬相关基因; ESCRT：转运所需的内体分选复合物; ILV：腔内囊泡
ABSTRACT The macroautophagy/autophagy pathway includes successive steps of phagophore assembly structure formation, phagophore expansion, autophagosome (AP) closure and AP fusion with the lysosome/vacuole. Although information about regulators, factors and molecular mechanisms important for early and late steps of autophagy is abundant, information about AP closure is scarce. In 2017, we reported that the Vps21/RAB5 GTPase module regulates AP closure in yeast. In a recent paper, we show that Vps21 regulates the recruitment of ESCRT to APs to catalyze their closure by controlling an Atg17-Snf7 interaction. Thus, we identify a regulator, a factor, and a molecular mechanism important for AP closure. Abbreviations: AP: Autohagosome; Atg: autophagy-related gene; ESCRT: the endosomal sorting complex required for transport; ILVs: intralumenal vescicles