Cognitive, cardiac, and physiological safety studies in ultra high field magnetic resonance imaging
Cognitive, cardiac, and physiological safety studies in ultra high field magnetic resonance imaging
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DOI：
10.1016/s0730-725x(99)00086-7
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发表时间：
1999-12-01
影响因子：
2.5
通讯作者：
Robitaille, PML
中科院分区：
文献类型：
--
作者：
Kangarlu, A;Burgess, RE;Robitaille, PML
一个8.0特斯拉的静磁场对生理和/或认知功能的影响的系统分析，在正常志愿者和猪。一项对10名人类受试者的研究显示，暴露1小时后，体温、心率、呼吸频率、收缩压和舒张压均未出现可检测到的变化。此外，未检测到认知变化。观察到与受试者在磁体中的位置和磁场的绝对强度相关的重要ECG变化。因此，8特斯拉的ECG描记在诊断上没有用。尽管如此，所有受试者在暴露于8特斯拉场之前和之后都表现出正常的ECG读数。还详细检查了猪的心脏功能。暴露于8.0特斯拉的场强3小时后，体温、心率、左心室压力、左心室末压、左心室压力变化率、心肌僵硬指数、心输出量、收缩期容积、肌钙蛋白和钾水平均无显著变化。得出的结论是，没有短期的心脏或认知功能的影响，观察后显着暴露于高达8.0特斯拉的磁场。(C)1999 Elsevier Science Inc.
A systematic analysis of the effect of an 8.0 tesla static magnetic field on physiological and/or cognitive function is presented in the normal volunteer and in the swine. A study of ten human subjects revealed no evidence of detectable changes in body temperature, heart rate, respiratory rate, systolic pressure, and diastolic blood pressure after 1 hour of exposure. In addition, no cognitive changes were detected. Important ECG changes were noted which were related both to the position of the subject in the magnet and to the absolute strength of the magnetic field. As such, the ECG tracing at 8 tesla was not diagnostically useful. Nonetheless, all subjects exhibited normal ECG readings both before and following exposure to the 8 tesla field. Cardiac function was also examined in detail in the swine. No significant changes in body temperature, heart rate, left ventricular pressure, left ventricular end diastollic pressure, time rate of change of left ventricular pressure, myocardial stiffness index, cardiac output, systolic volume, troponin, and potassium levels could be detected following 3 h of exposure to a field strength of 8.0 tesla. It is concluded that no short term cardiac or cognitive effects are observed following significant exposure to a magnetic field of up to 8.0 tesla. (C) 1999 Elsevier Science Inc.