Viral exploitation of the MEK/ERK pathway - A tale of vaccinia virus and other viruses
Viral exploitation of the MEK/ERK pathway - A tale of vaccinia virus and other viruses
复制标题
DOI：
10.1016/j.virol.2016.12.011
复制
发表时间：
2017-07-01
期刊：
影响因子：
3.7
通讯作者：
Bonjardim, Claudio A.
中科院分区：
文献类型：
--
作者：
Bonjardim, Claudio A.
VACV复制循环是显著的，因为它完全在脊椎动物细胞的细胞质区室中进行，这是由于其编码调节大分子前体库或生物合成过程所需的酶的能力。虽然值得注意，但这种基因库不足以赋予病毒自由生活微生物的地位，因此，病毒严重依赖宿主成功产生其后代。在复杂的病毒-宿主相互作用期间，病毒不仅必须处理宿主途径以实现其时间需求，而且还必须处理抵抗病毒感染的途径，包括炎症、先天性和获得性免疫应答。本文综述了VACV和其他DNA或RNA病毒，刺激MEK（MAPK -丝裂原活化蛋白激酶）/ERK-细胞外信号调节激酶）途径作为其复制周期的一部分。
The VACV replication cycle is remarkable in the sense that it is performed entirely in the cytoplasmic compartment of vertebrate cells, due to its capability to encode enzymes required either for regulating the macromolecular precursor pool or the biosynthetic processes. Although remarkable, this gene repertoire is not sufficient to confer the status of a free-living microorganism to the virus, and, consequently, the virus relies heavily on the host to successfully generate its progeny. During the complex virus-host interaction, viruses must deal not only with the host pathways to accomplish their temporal demands but also with pathways that counteract viral infection, including the inflammatory, innate and acquired immune responses. This review focuses on VACV and other DNA or RNA viruses that stimulate the MEK (MAPK - Mitogen Activated Protein Kinase)/ERK-Extracellular signal-Regulated Kinase) pathway as part of their replication cycle.