FMRI brain activation in response to odors is reduced in primary olfactory areas of elderly subjects
FMRI brain activation in response to odors is reduced in primary olfactory areas of elderly subjects
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DOI：
10.1016/s0006-8993(03)03168-8
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发表时间：
2003-10-03
期刊：
影响因子：
2.9
通讯作者：
Murphy, C
中科院分区：
文献类型：
--
作者：
Cerf-Ducastel, B;Murphy, C
嗅觉功能会受到衰老的影响，而嗅觉缺陷往往会导致生活质量、健康和安全的下降。本研究用功能性磁共振成像(FMRI)研究了与衰老有关的嗅觉缺陷的皮质基质，采用鼻后嗅觉刺激方案，使用口中提供的有风味的水溶液。在年轻受试者的梨状/杏仁体区域和眼眶额叶皮质以及之前使用气味空气进行的神经成像研究中发现的其他区域，包括脑岛和小脑，都发现了激活。在老年受试者中也可以看到类似区域的激活，但在接受初级嗅觉投射的区域(梨状皮质、内嗅觉皮质和杏仁核)的激活程度明显较低。这一结果支持了这一假说，即嗅觉加工的关键区域的功能障碍和/或退化是老年人嗅觉缺陷的主要原因。(C)2003爱思唯尔B.V.保留所有权利。
Olfactory function is affected by aging and deficits often result in decreasing quality of life, health and safety. The present study investigated the cortical substrate of olfactory deficits related to aging with functional Magnetic Resonance Imaging (fMRI), with a retronasal olfactory stimulation protocol using flavored aqueous solutions presented to the mouth. Activation was found in young subjects in the piriform/amygdalar region and in the orbitofrontal cortex and in other areas previously found activated in neuroimaging studies using odorized air, including insula and cerebellum. Activation was seen in similar areas in old subjects but the degree of activation was significantly lower in regions receiving primary olfactory projections (piriform cortex, entorhinal cortex, and amygdala). This result supports the hypothesis of dysfunction and/or degeneration in areas critical to olfactory processing as a major cause of olfactory deficits in the older population. (C) 2003 Elsevier B.V. All rights reserved.