Chronotropic and Dromotropic Effects of Adenosine
Chronotropic and Dromotropic Effects of Adenosine
复制标题
腺苷的变时性和变速作用
DOI：
10.1007/978-1-4613-3909-0_24
复制
发表时间：
1983
期刊：
影响因子：
37.8
通讯作者：
R. Berne
中科院分区：
文献类型：
--
作者：
L. Belardinelli;A. West;R. Crampton;R. Berne
自1929年以来，已知腺苷可减慢窦性心率并导致房室（A-V）阻滞[1]。尽管腺苷的冠状血管扩张作用在过去二十年中受到了相当大的关注，但关于腺苷对心肌和专门传导系统的直接影响的报道相对较少。在豚鼠心脏中观察到的A-V阻滞首先引起了Drury和Szent-Gyorgyi对核酸衍生物生理活性的注意，这不仅仅是历史上的兴趣。他们使用豚鼠的房室传导阻滞诱导作为一种生物测定，以检测心肌提取物中是否存在一种物质，后来发现这种物质是腺苷酸。从酵母核酸中获得的腺苷随后显示出具有类似的作用[1]。
Since 1929, adenosine has been known to slow sinus rate and cause atrioventricular (A-V) block [1]. Although the coronary vasodilator action of adenosine has received considerable attention in the last two decades, reports on the direct effects of adenosine on the myocardium and specialized conduction system have been relatively few. It is of more than historic interest that the A-V block observed in the guinea pig heart first drew the attention of Drury and Szent-Gyorgyi to the physiologial activity of the nucleic acid derivatives. They used the induction of A-V block in guinea pigs as a bioassay for the presence of a substance derived from heart muscle extracts, later found to be adenylic acid. Adenosine obtained from yeast nucleic acid was subsequently shown to have a similar action [1].