Pleiotropic roles of melatonin in endometriosis, recurrent spontaneous abortion, and polycystic ovary syndrome
Pleiotropic roles of melatonin in endometriosis, recurrent spontaneous abortion, and polycystic ovary syndrome
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褪黑激素在子宫内膜异位症、复发性流产和多囊卵巢综合征中的多效作用
DOI：
10.1111/aji.12839
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发表时间：
2018
影响因子：
3.6
通讯作者：
Li MQ
中科院分区：
文献类型：
--
作者：
Yang Hui-Li;Zhou Wen-Jie;Gu Chun-Jie;Li Da-Jin;Li Ming-Qing;Shao Jun;Meng Yu-Han;Li MQ
褪黑素是一种由芳香氨基酸色氨酸合成的神经激素，主要由哺乳动物的松果腺合成。褪黑素是一种广谱抗氧化剂、强大的自由基清除剂、抗炎剂、抗癌因子、睡眠诱导剂和昼夜节律调节剂，以及潜在的免疫调节剂。褪黑素与生殖系统在生理和病理条件下都是相互联系的。氧化应激、炎症和免疫失调与女性生殖系统的发病有关，导致子宫内膜异位症(EMS)、复发性自然流产(RSA)和多囊卵巢综合征(PCOS)。越来越多的研究表明，褪黑素在这些妇产科疾病中起着多效性和必不可少的作用，有望成为调节炎症和免疫功能、保护特殊细胞或器官的候选治疗药物。在这里，我们系统地综述褪黑素在EMS、RSA和PCOS中的多效性作用，以探索其病理意义和治疗潜力。
Melatonin is a neurohormone synthesized from the aromatic amino acid tryptophan mainly by the pineal gland of mammals. Melatonin acts as a broad‐spectrum antioxidant, powerful free radical scavenger, anti‐inflammatory agent, anticarcinogenic factor, sleep inducer and regulator of the circadian rhythm, and potential immunoregulator. Melatonin and reproductive system are interrelated under both physiological and pathological conditions. Oxidative stress, inflammation, and immune dysregulation are associated with the pathogenesis of the female reproductive system which causes endometriosis (EMS), recurrent spontaneous abortion (RSA), and polycystic ovary syndrome (PCOS). Accumulating studies have indicated that melatonin plays pleiotropic and essential roles in these obstetrical and gynecological disorders and would be a candidate therapeutic drug to regulate inflammation and immune function and protect special cells or organs. Here, we systematically review the pleiotropic roles of melatonin in EMS, RSA, and PCOS to explore its pathological implications and treatment potential.