NKCC1 and NKCC2: The pathogenetic role of cation-chloride cotransporters in hypertension.
NKCC1 and NKCC2: The pathogenetic role of cation-chloride cotransporters in hypertension.
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DOI：
10.1016/j.gendis.2015.02.007
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发表时间：
2015-06
期刊：
影响因子：
6.8
通讯作者：
Dulin, Nickolai O
中科院分区：
文献类型：
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作者：
Orlov, Sergei N;Koltsova, Svetlana V;Kapilevich, Leonid V;Gusakova, Svetlana V;Dulin, Nickolai O
本文综述了电中性钠、钾和氯共转运体泛在型（NKCC1）和肾特异性（NKCC2）同工型的功能意义。这些载体分别通过调节血管平滑肌和神经元细胞内的氯离子浓度以及感知肾小管液中的氯离子浓度来促进高血压的发病。NKCC1和NKCC2均被速尿和其他广泛用于减少细胞外液容量的高上限利尿剂抑制。然而，长期使用这些化合物治疗高血压和其他容量扩张性疾病可能会由于抑制微循环床的肌生成反应而产生各种副作用。
This review summarizes the data on the functional significance of ubiquitous (NKCC1) and renal-specific (NKCC2) isoforms of electroneutral sodium, potassium and chloride cotransporters. These carriers contribute to the pathogenesis of hypertension via regulation of intracellular chloride concentration in vascular smooth muscle and neuronal cells and via sensing chloride concentration in the renal tubular fluid, respectively. Both NKCC1 and NKCC2 are inhibited by furosemide and other high-ceiling diuretics widely used for attenuation of extracellular fluid volume. However, the chronic usage of these compounds for the treatment of hypertension and other volume-expanded disorders may have diverse side-effects due to suppression of myogenic response in microcirculatory beds.