Helicobacter pylori and the gastric microbiota
Helicobacter pylori and the gastric microbiota
复制标题
DOI：
10.1016/j.bpg.2013.03.016
复制
发表时间：
2013-02-01
影响因子：
3.2
通讯作者：
Lindberg, Mathilda
中科院分区：
文献类型：
--
作者：
Engstrand, Lars;Lindberg, Mathilda
沿着胃肠道的人类微生物群沿着目前被广泛研究，并且许多研究集中于阐明或多或少不同的肠道微生物群落与健康和疾病之间的关联。人类胃被认为是专门由幽门螺杆菌居住，并且进一步缺乏定殖的非H。幽门螺杆菌植物群由于酸性环境。然而，最近使用基于分子的方法进行的有限数量的研究提供了胃微生物群的更广泛的图片。问题是胃pH值的变化或抗生素治疗是否会导致胃微生物群的显著变化，这些微生物群可能与胃癌等疾病的发展有关。(c)2013由Elsevier Ltd.出版
The human microbiota along the gastrointestinal tract is currently extensively studied and a number of studies focuses on elucidating the association between a more or less diverse intestinal microbial community and health and disease. The human stomach is considered to be exclusively inhabited by Helicobacter pylori and further lacks a colonizing non-H. pylori bacterial flora due to the acidic environment. However, recently a limited number of studies using molecular-based methods have provided a broader picture of the stomach microbiota. The question is whether changes in gastric pH or antibiotic treatment can lead to significant shifts in the stomach microbiota that may be involved in disease development such as gastric cancer. (c) 2013 Published by Elsevier Ltd.