Ridge preservation of extraction sockets with buccal bone deficiency using poly lactide-co-glycolide coated β-tricalcium phosphate bone grafts: An experimental study in dogs
Ridge preservation of extraction sockets with buccal bone deficiency using poly lactide-co-glycolide coated β-tricalcium phosphate bone grafts: An experimental study in dogs
复制标题
使用聚丙交酯-乙交酯涂层β-磷酸三钙骨移植物保存颊骨缺损拔牙窝牙槽嵴：犬的实验研究
DOI：
10.1002/jper.18-0574
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发表时间：
2019
影响因子：
4.3
通讯作者：
Izumi Yuichi
中科院分区：
文献类型：
--
作者：
Okada Munehiro;Matsuura Takanori;Akizuki Tatsuya;Hoshi Shu;Shujaa Addin Ammar;Fukuba Shunsuke;Izumi Yuichi
背景拔牙后牙槽嵴高度和宽度明显减小。本研究的目的是比较评估潜在的牙槽嵴保存与颊骨缺损的β-磷酸三钙涂层与聚乳酸-共-乙交酯（β-TCP/PLGA）和传统的颗粒β-TCP.MethodsIn六只比格犬，上颌第一前磨牙被提取后，去除他们的颊骨板。在拔牙窝部位创建标准化骨缺损（4 [近中远端宽度] × 4 [颊腭宽度] × 5 [深度] mm），并用β-TCP/PLGA（试验部位）或颗粒β-TCP（对照部位）填充。术后12周进行显微计算机断层扫描、组织学和组织测量学评价。ResultsThe test site showed a significant greater bone volume than the control sites（25.7 ± 2.14与16.0 ± 3.3 mm 3），尽管在骨材料密度方面未检测到统计学显著差异（分别为746.3 ± 23.9和714.5 ± 37.0 g/cm 3）。相对于对照部位，测试部位的牙槽嵴冠状面（2.0 ± 0.4与1.1 ± 0.3 mm）和中等（2.9 ± 0.2与2.1 ± 0.3 mm）编织骨的水平宽度和比例（50.3 ± 8.1% vs 38.0 ± 5.2%）和骨髓（17.7 ± 6.6% vs 9.7 ± 4.1%），但结缔组织比例显著较低（10.7 ± 4.5%对18.3 ± 5.7%）。结论在本研究的范围内，可模塑的β-TCP/PLGA移植物似乎比传统的颗粒β-TCP移植物更有潜力用于颊侧骨缺损的拔牙窝的牙槽嵴保存。
BackgroundThe alveolar ridge undergoes pronounced reduction in height and width following tooth extraction. This study aims to comparatively evaluate the potential for ridge preservation in extraction sockets with buccal bone deficiency of β‐tricalcium phosphate coated with poly lactide‐co‐glycolide (β‐TCP/PLGA) and conventional particulate β‐TCP.MethodsIn six beagles, maxillary first premolars were extracted after removal of their buccal bone plates. Standardized bone defects (4 [mesiodistal width] × 4 [buccopalatal width] × 5 [depth] mm) were created at the sites of extraction sockets and filled with β‐TCP/PLGA (test sites) or particulate β‐TCP (control sites). Microcomputed tomography, histologic, and histometric evaluations were performed 12 weeks post‐surgery.ResultsThe test sites exhibited a significantly greater bone volume than the control sites (25.7 ± 2.14 versus 16.0 ± 3.3 mm3), although no statistically significant difference was detected in bone material density (746.3 ± 23.9 versus 714.5 ± 37.0 g/cm3, respectively). Relative to the control sites, the test sites exhibited significantly greater alveolar‐ridge coronal (2.0 ± 0.4 versus 1.1 ± 0.3 mm) and middle (2.9 ± 0.2 versus 2.1 ± 0.3 mm) horizontal widths and proportions of woven bone (50.3 ± 8.1% versus 38.0 ± 5.2%) and bone marrow (17.7 ± 6.6% versus 9.7 ± 4.1%) but a significantly lower proportion of connective tissue (10.7 ± 4.5% versus 18.3 ± 5.7%).ConclusionWithin the limitations of this study, the moldable β‐TCP/PLGA graft appears to exhibit a greater potential than the conventional particulate β‐TCP graft for ridge preservation of extraction sockets with buccal bone deficiency.